Table 2. The number of communication pathways between the active region and the other residues more than the frequency of 30%.
Cnt-wat | Free-wat | Cnt-acn | Free-acn | Cnt-hep | Free-hep | |
---|---|---|---|---|---|---|
Totala | 2263 | 2101 | 3301 | 3030 | 2985 | 2814 |
G100-Y103b | 50 | 0 | 162 | 33 | 130 | 0 |
S125-G128c | 194 | 155 | 295 | 271 | 298 | 260 |
catalytic triadd | 123 | 107 | 190 | 188 | 175 | 165 |
aThe number of pathways from the other residues to the active region consisted of the substrate-binding pocket and the three catalytic residues.
bThe number of pathways from the other residues to G100-Y103.
cThe number of pathways from the other residues to S125-G128.
dThe number of pathways from the other residues to the three catalytic residues.