Table 2. The number of communication pathways between the active region and the other residues more than the frequency of 30%.

	Cnt-wat	Free-wat	Cnt-acn	Free-acn	Cnt-hep	Free-hep
Totala	2263	2101	3301	3030	2985	2814
G100-Y103b	50	0	162	33	130	0
S125-G128c	194	155	295	271	298	260
catalytic triadd	123	107	190	188	175	165

^aThe number of pathways from the other residues to the active region consisted of the substrate-binding pocket and the three catalytic residues.

^bThe number of pathways from the other residues to G100-Y103.

^cThe number of pathways from the other residues to S125-G128.

^dThe number of pathways from the other residues to the three catalytic residues.