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. 2016 Nov 22;6:37336. doi: 10.1038/srep37336

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Copyright © 2016, The Author(s)

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For each measurement, the ice-cold mitochondria were incubated with medium alone, 5-HTR3/5-HTR4 agonists, or CsA at room temperature for 10 min prior to the experiments. 200 uM of Ca2+ was added at 60 s with a quick mix. (A) CsA and m-Chlorophenylbiguanide hydrochloride (5-HTR3 agonist) attenuated the mPTP opening; (B) BIMU attenuated the mPTP opening; (C) Inhibitory effects of 5-HTR3 and 5-HTR4 on mPTP opening. The bars represents the A/Ao at 300 s and 500 s of each experimental groups respectively, n > 8 at each column. (D) AC inhibitor overcame the effect on mPTP opening caused by BIMU at 500 seconds.