Table 1. Top 25 retinal genes sorted by P-value, following transmammary-delivered immunoblocking of BMP9 and BMP10.
| Gene Symbol | Ensembl Gene ID | Gene Description | Log Fold Change | Adjusted P-Value |
|---|---|---|---|---|
| Angpt2 | ENSMUSG00000031465 | angiopoietin 2 | 0.71358 | 2.69E-08 |
| Ighv6-3 | ENSMUSG00000076677 | immunoglobulin heavy variable 6-3 | 0.97880 | 3.77E-08 |
| Sarm1 | ENSMUSG00000050132 | sterile alpha and HEAT/Armadillo motif containing 1 | 1.19426 | 6.39E-08 |
| Pfkp | ENSMUSG00000021196 | phosphofructokinase, platelet | 0.88318 | 9.18E-08 |
| mt-Tw | ENSMUSG00000064346 | mitochondrially encoded tRNA tryptophan | 0.88100 | 9.00E-07 |
| mt-Ta | ENSMUSG00000064347 | mitochondrially encoded tRNA alanine | 0.71786 | 1.02E-06 |
| Col4a1 | ENSMUSG00000031502 | collagen, type IV, alpha 1 | 0.70214 | 1.18E-06 |
| Gga3 | ENSMUSG00000020740 | golgi associated, gamma adaptin ear containing, ARF binding protein 3 | 0.98161 | 6.11E-06 |
| Fitm2 | ENSMUSG00000048486 | fat storage-inducing transmembrane protein 2 | 0.97348 | 7.73E-06 |
| Fam118b | ENSMUSG00000050471 | family with sequence similarity 118, member B | 1.00344 | 9.88E-06 |
| mt-Tk | ENSMUSG00000064355 | mitochondrially encoded tRNA lysine | 0.91010 | 1.18E-05 |
| Cd248 | ENSMUSG00000056481 | CD248 antigen, endosialin | 0.87747 | 2.45E-05 |
| Masp2 | ENSMUSG00000028979 | mannan-binding lectin serine peptidase 2 | −1.03437 | 2.47E-05 |
| Stab2 | ENSMUSG00000035459 | stabilin 2 | −0.73237 | 2.76E-05 |
| Fam160a2 | ENSMUSG00000044465 | family with sequence similarity 160, member A2 | 0.91040 | 2.76E-05 |
| Gm13412 | ENSMUSG00000085017 | predicted gene 13412 | 1.11272 | 3.08E-05 |
| Car10 | ENSMUSG00000056158 | carbonic anhydrase 10 | 2.50842 | 3.47E-05 |
| 4933431K23Rik | ENSMUSG00000086451 | RIKEN cDNA 4933431K23 gene | 0.93124 | 3.68E-05 |
| Myo9a | ENSMUSG00000039585 | myosin IXa | 1.07037 | 4.02E-05 |
| Entpd8 | ENSMUSG00000036813 | ectonucleoside triphosphate diphosphohydrolase 8 | 1.15946 | 4.45E-05 |
| Cbx6 | ENSMUSG00000089715 | chromobox 6 | 0.75546 | 4.45E-05 |
| Gm17828 | ENSMUSG00000098893 | predicted gene, 17828 | −0.87768 | 4.84E-05 |
| Khsrp | ENSMUSG00000007670 | KH-type splicing regulatory protein | 0.72962 | 4.84E-05 |
| Col15a1 | ENSMUSG00000028339 | collagen, type XV, alpha 1 | 1.13494 | 5.05E-05 |
The first 25 genes with adjusted P-value (false discovery rate) less or equal to 1%, and abs(logFC) ≥ 0.7, sorted by increasing adjusted P-value, are shown. Gene expression changes are expressed in log2 fold change and compare anti-BMP9/10 Ab-treated versus control IgG2a/2b-treated retinas. Positive logFC values denote genes over-expressed in anti-BMP9/10 Ab-treated retinas. A log2 fold change value of 1 corresponds to a doubling of expression in treated retinas (log2(2) = 1).