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. 2016 Nov 22;6:36905. doi: 10.1038/srep36905

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Copyright © 2016, The Author(s)

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(a) Representation of infliximab, an IgG1 with two Fabs that are linked together through the hinge as if each Fab is linked at the end of a linear molecule. Proteolytical digestion of IgG1 yield the Fabs fragment which are then treated with DTT and then linked to each end of PEG di(mono-sulfone) reagent 2 to make FpF, (b) PEG di(mono-sulfone) reagent 2 is synthesised from PEG di(bis-sulfone) reagent 1 through elimination of toluene sulfinic acid anion (c) The FpF_infliximab is synthesized in a way to compare directly to the starting infliximab. This strategy is applicable on different kind of monoclonal IgGs such as human, humanised and chimeric IgGs.