Figure 2.

Molecular diagnostics for determination of Pluripotency. Various research groups have demonstrated the molecular markers especially TFs which essentially regulate the self-renewal and differentiation potential of PSCs. These factors either directly regulate renewal/ differentiation through their binding to the target gene and therefore regulating target gene expression; or they themselves get regulated and are the target for a number of other transcription regulating elements such as miTNA, Noncoding RNA, Histone modifiers. Various researchers have wisely used these factors as the marker to define the potential of any test cells as an alternate approach to the standard functional assays.