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. 2016 Nov 22;6:36858. doi: 10.1038/srep36858

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(a) Modelled binding mode of oleanyl cation (cyan), (b) β-amyrin (orange) and (c) poses overlay within MiFRS^Leu482Thr mutant binding site: the water molecule is indicated as red sphere, and polar interaction between Tyr259 and oleanyl cation (magenta) is indicated as yellow dashed lines. (d) Modelled binding mode of oleanyl cation (cyan), (e) friedelin (orange) and (f) poses overlay within MiFRS^Leu482Val mutant binding site: polar interaction between Tyr259 and oleanyl cation (magenta) is indicated as yellow dashed lines.