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. 2016 Nov 22;17:953. doi: 10.1186/s12864-016-3299-5

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 8 — NRPS phylogenetic tree 1. The amino acid sequences of the A domain from 153 mostly mono-modular fungal and bacterial NRPS were used to construct the phylogenetic tree. Numerals at the nodes represent the percentages from 500 bootstraps. Numeral <50 were omitted. Scale: number of substitutions per nucleotide. Colored backgrounds indicate enzyme groups: Sid, siderophore synthetases; NPS11/NPS12, NPS11/12-like NRPS and ETP toxin synthetases; Cyclo, cyclosporine synthetases; MBC, major bacterial clade; AAR, α-amino-adipate reductases; NPS10, NRPS 10-like NRPS; PKS-NPS, hybrid enzymes. Orange-framed boxes mark members of outgroups