Table 2.
Serum lipid results, CAG and OCT measurements at baseline and follow-up
| Variables | Baseline | Follow-up | p-value |
|---|---|---|---|
| Serum lipid | |||
| Total cholesterol, mg/dl | 198.6 ± 42.2 | 146.1 ± 40.0 | <0.001 |
| LDL-C, mg/dl | 109.4 ± 24.6 | 73.9 ± 29.2 | <0.001 |
| HDL-C, mg/dl | 49.3 ± 12.3 | 46.7 ± 13.9 | 0.123 |
| LDL-C/HDL-C | 2.3 ± 0.8 | 1.7 ± 0.7 | <0.001 |
| Triglycerides, mg/dl | 215.7 ± 151.7 | 140.2 ± 64.3 | <0.001 |
| Apolipoprotein B, mg/dl | 89.0 ± 24.1 | 63.3 ± 25.2 | <0.001 |
| OCT quantitative data | |||
| Fibrous-cap thickness, μm | 61.1 ± 18.5 | 159.1 ± 78.9 | <0.001 |
| Maximum lipid arc, ° | 241.2 ± 69.9 | 206.4 ± 75.3 | <0.001 |
| Mean lipid arc, ° | 174.8 ± 51.6 | 152.5 ± 55.7 | <0.001 |
| Lipid length, mm | 9.9 ± 4.7 | 9.3 ± 4.9 | 0.010 |
| Lipid index | 1783.4 ± 1038.7 | 1476.0 ± 1042.7 | <0.001 |
| OCT qualitative data, n (%) | |||
| TCFA | 63 (64.9%) | 13 (13.4%) | <0.001 |
| Macrophage | 71 (73.2%) | 58 (59.8) | 0.019 |
| Micro-vessel | 44 (45.4) | 29 (29.9) | 0.004 |
| Cholesterol crystal | 23 (23.7) | 10 (10.3) | 0.002 |
| Thrombus | 6 (6.2) | 0 | N/A |
| Spotty calcification | 25 (26.0) | 24 (24.7) | 1.000 |
| Disruption | 9 (9.3) | 0 | N/A |
| CAG quantitative data | |||
| Minimal lumen diameter, mm | 2.0 ± 0.5 | 2.0 ± 0.5 | 0.824 |
| Diameter stenosis, % | 28.9 ± 10.5 | 29.5 ± 11.1 | 0.530 |
| Lesion length, mm | 11.3 ± 5.1 | 11.7 ± 5.0 | 0.069 |
Data are presented as mean ± SD or n (%). Quantitative data at baseline and at follow-up are compared using paired t test and qualitative data using McNemar test. CAG coronary Angiography, LDL-C low-density lipoprotein cholesterol, HDL-C high-density lipoprotein cholesterol, OCT optical coherence tomography, TCFAs thin-cap fibroatheromas; N/A not applicable. A p-value < 0.05 was considered statistically significant. ° arc of lipid content.