Table 2.
Genotype distribution of DNMT3B −149C>T and −2437T>A polymorphisms and their associations with lung cancer risk
| Genotype | No. of cases (%) | No. of controlsa (%) | ORb (95% CI) | P value |
|---|---|---|---|---|
| −149C>T | ||||
| TT | 35 (5.1) | 38 (6.3) | 0.90 (0.62 2.37) | 0.406 |
| CT | 249 (36.4) | 172 (28.6) | 1.42 (0.34 1.53) | 0.541 |
| CC | 400 (58.5) | 392 (65.1) | Reference | |
| T-allele carriers | 284 (41.5) | 210 (34.9) | 0.78 (0.57 1.05) | 0.361 |
| −2437T>A | ||||
| AA | 76 (11.1) | 56 (9.3) | 1.22 (0.58 1.35) | 0.215 |
| TA | 269 (39.4) | 241 (40.1) | 1.00 (0.42 1.67) | 0.308 |
| TT | 339 (49.5) | 304 (50.6) | Reference | |
| A-allele carriers | 345 (50.5) | 297 (49.4) | 0.99 (0.74, 1.33) | 0.167 |
No. number of cases or controls, OR odds ratio, CI confidence interval
aThe observed genotype distribution in controls was in accordance with the Hardy-Weinberg equilibrium (P = 0.153 for DNMT3B −149C>T and P = 0.187 for DNMT3B −2437T>A)
bAdjusted for age and sex in a logistic regression model