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Model for the α-arrestin-mediated endocytosis of the cellobiose transporters. The α-arrestins Rod1, Rog3, Aly1, and Aly2 cooperate to mediate the recruitment of Rsp5 to the ectopically expressed cellobiose transporters. Rsp5 brings about the ubiquitinylation of the transporters, which are subsequently endocytosed.
