FIG 2.

Production of mevalonate after chromosomal integration of the mevalonate pathway. (A) Glucose concentration in the fermentation medium at indicated time. (B) Accumulation of acetate by-product. Mevalonate titers (C) and yields (D) achieved from plasmid-based fermentation (BW25113/pMEV-7), or after chromosomal integration of the mevalonate pathway (CMEV-1 and CMEV-2). Error bars represent the standard deviation (from three different cultures). The standard deviations are often small and masked by the data symbols.