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A summary of the amino acid residues of IgGl-Fc glycoforms modified during the accelerated and forced degradation studies.
| Amino acid | Products detected by HPLC-MS/MS analysis | |
|---|---|---|
| Accelerated degradation | Forced degradation | |
| Asn315 | Asn315 deamidation | Asn315 deamidation |
| Met428 | - | Met sulfoxide |
| Trp277 |
|
Not observed |
| Trp313 and Lys317 | Not observed |
|
