Table 1.
The effect of fasting on the plasma lipid profile and circulating ghrelin in female W-T and PWS-ICdel littermate mice.
W-T female | PWC-ICdel female | |||
---|---|---|---|---|
Fed (n = 9) | Fasted (n = 9) | Fed (n = 8) | Fasted (n = 4) | |
Body weight (g) | 43.1 ± 3.0 | 42.2 ± 2.6 | 26.2 ± 0.7aaa | 22.9 ± 1.1ccc |
Total polar lipids (µg/µL) | 0.313 ± 0.021 | 0.366 ± 0.043 | 0.247 ± 0.014 | 0.269 ± 0.040 |
Free fatty acids (µg/µL) | 0.045 ± 0.004 | 0.072 ± 0.013 | 0.049 ± 0.017 | 0.069 ± 0.021 |
Triacylglycerol (µg/µL) | 0.191 ± 0.026 | 0.105 ± 0.023 | 0.128 ± 0.031 | 0.085 ± 0.042 |
S1 sterol esters (µg/µL) | 0.036 ± 0.005 | 0.057 ± 0.011 | 0.029 ± 0.005 | 0.025 ± 0.009 |
S2 sterol esters (µg/µL) | 0.058 ± 0.004 | 0.058 ± 0.010 | 0.045 ± 0.007 | 0.030 ± 0.009 |
Plasma [ghrelin (total)] (ng/mL) | 9.82 ± 2.24 | 54.94 ± 10.03aa | 13.12 ± 1.95 | 62.86 ± 15.43bb |
S1, arachidonic acid-enriched sterol esters;
S2, sterol esters with shorter chain fatty acids.
P < 0.01
P < 0.001 vs fed W–T female
P < 0.01 vs fed PWC-ICdel female
P < 0.001 vs fasted W-T female.