TABLE 3.
Final overall model pharmacokinetic parametersa
| Author(s), yr (reference no.) | AUC (mg · h/liter) | Cmax (mg/liter) | kel (h−1) | t1/2b (h) | Tmax (h) | Absorption t1/2 (h) | Ka (h−1) | V/F (liters) | CL/F (liters/h) |
|---|---|---|---|---|---|---|---|---|---|
| Overall | 51.31 (45.01, 60.28) | 2.19 (2.06, 2.33) | 0.05 (0.04, 0.06) | 13.27 (11.79, 15.42) | 2.93 (2.57, 3.48) | 0.60 (0.38, 1.11) | 1.16 (0.59, 1.76) | 39.19 (36.58, 42.17) | 2.04 (1.77, 2.32) |
| Bronn, 2015 (17) | 50.05 (45.91, 54.34) | 2.20 (2.06, 2.34) | 0.05 (0.05, 0.06) | 12.95 (12.03, 13.95) | 2.75 (2.41, 3.17) | 0.59 (0.49, 0.72) | 1.18 (0.96, 1.41) | 39.16 (36.69, 42.04) | 2.09 (1.93, 2.29) |
| Peregrina Lucano, 2004 (20) | 54.82 (48.20, 64.40) | 2.11 (1.92, 2.29) | 0.05 (0.04, 0.06) | 14.02 (12.26, 16.66) | 3.65 (2.77, 5.27) | 0.85 (0.58, 1.44) | 0.82 (0.48, 1.20) | 39.38 (36.79, 42.55) | 1.95 (1.65, 2.23) |
| Raaflaub and Ziegler, 1979 (22) | 49.76 (44.66, 55.38) | 2.26 (2.09, 2.44) | 0.05 (0.05, 0.06) | 12.94 (11.84, 14.28) | 2.35 (1.92, 2.93) | 0.47 (0.36, 0.64) | 1.46 (1.08, 1.92) | 39.04 (36.27, 42.01) | 2.09 (1.87, 2.33) |
a
Data represent the mean (95% CrI).
b
t1/2, half-life.