TABLE 5.
Plasma PK parameters of ritonavir after single-dose administration of narlaprevir with ritonavir (part 2) in patients with compensated cirrhosis and in healthy subjectsa
| Parameter | Cirrhotic patients (n = 8) |
Healthy subjects (n = 8) |
P/H | ||
|---|---|---|---|---|---|
| GMEAN | CV (%) | GMEAN | CV (%) | ||
| Cmax (ng/ml) | 0.556 | 80.5 | 0.384 | 20.3 | 1.45 |
| AUC0–last (ng · h/ml) | 5.198 | 66.1 | 3.178 | 21.7 | 1.64 |
| Tmax (h) | 4.0 | 52.1 | 4.2 | 34.4 | 0.9 |
a
Cmax and AUC values are presented as arithmetic means, and Tmax values are presented as medians. P/H, patient/healthy subject ratio; CV, coefficient of variation.