TABLE 1.
MICs of AR-12 against fungal pathogens
| Species | No. of isolates | AR-12 MIC (μg/ml) | MIC range (μg/ml)a |
||
|---|---|---|---|---|---|
| FLU | VOR | POS | |||
| Candida albicans | 10 | 2–4 | 0.5 to >254 | ND | ND |
| C. glabrata | 14 | 4 | 2–64 | ND | ND |
| C. parapsilosis | 8 | 2–4 | 2–4 | ND | ND |
| C. tropicalis | 1 | 4 | ND | ND | ND |
| C. krusei | 1 | 4 | ND | ND | ND |
| C. guilliermondii | 7 | 2–4 | 1–8 | ND | ND |
| Cryptococcus neoformans | 4 | 4 | 2–64 | ND | ND |
| Fusarium oxysporum | 2 | 4 | ND | 16 | ND |
| F. solani | 1 | 4 | ND | ND | 8 |
| Scedosporium apiospermum | 2 | 2 | ND | 0.5–16 | ND |
| Paecilomyces variotii | 1 | 4 | ND | 0.25 | 0.125 |
| Lomentospora prolificans | 1 | 2 | ND | ND | 16 |
| Rhizopus oryzae | 6 | 4 | ND | ND | 0.125–1 |
| Apophysomyces | 2 | 4 | ND | ND | 0.125–1 |
| Blastomyces dermatiditis | 3 | 0.5–2b | ND | 0.03–0.125 | ND |
| Coccidioides immitis | 3 | 4–8 | ND | 0.03–0.125 | ND |
| Histoplasma capsulatum | 4 | 0.25–1b | ND | 0.03–0.125 | ND |
a
VOR, voriconazole; POS, posaconazole; ND, not determined.
b
The AR-12 MIC for these species is consistently 4 μg/ml based on a newly developed assay for H. capsulatum and B. dermatiditis (21).