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. 2016 Nov 21;60(12):7115–7127. doi: 10.1128/AAC.01061-16

TABLE 1.

MICs of AR-12 against fungal pathogens

Species No. of isolates AR-12 MIC (μg/ml) MIC range (μg/ml)a
FLU VOR POS
Candida albicans 10 2–4 0.5 to >254 ND ND
C. glabrata 14 4 2–64 ND ND
C. parapsilosis 8 2–4 2–4 ND ND
C. tropicalis 1 4 ND ND ND
C. krusei 1 4 ND ND ND
C. guilliermondii 7 2–4 1–8 ND ND
Cryptococcus neoformans 4 4 2–64 ND ND
Fusarium oxysporum 2 4 ND 16 ND
F. solani 1 4 ND ND 8
Scedosporium apiospermum 2 2 ND 0.5–16 ND
Paecilomyces variotii 1 4 ND 0.25 0.125
Lomentospora prolificans 1 2 ND ND 16
Rhizopus oryzae 6 4 ND ND 0.125–1
Apophysomyces 2 4 ND ND 0.125–1
Blastomyces dermatiditis 3 0.5–2b ND 0.03–0.125 ND
Coccidioides immitis 3 4–8 ND 0.03–0.125 ND
Histoplasma capsulatum 4 0.25–1b ND 0.03–0.125 ND
a

VOR, voriconazole; POS, posaconazole; ND, not determined.

b

The AR-12 MIC for these species is consistently 4 μg/ml based on a newly developed assay for H. capsulatum and B. dermatiditis (21).