TABLE 3.
Nonsynonymous mutations in AR-12-resistant S. cerevisiae strains
| Gene | Chromosome/position | Codon changea | Amino acid change | Presence of mutation in strain: |
||
|---|---|---|---|---|---|---|
| 16-14 | 16-77 | 64-77 | ||||
| TRA1 | VIII/304575 | AAC-AAA | N605K | + | + | + |
| YPR137-C | XVI/805261 | GTC-ATG | V1670 M | + | + | + |
| YPR137-C | XVI/805267 | CAC-TAC | H1668Y | + | + | + |
| SVL3 | XVI/489657 | GGC-AGC | G570S | + | − | + |
| YIL169C | IX/25418 | GAT-GGT | D230G | + | + | − |
| PDR1 | VII/469717 | TCT-TAT | S861Y | + | − | + |
| PDR1 | VII/469849 | ACA-AAA | T817K | − | + | − |
| KCC4 | III/81761 | AGT-AAT | S867N | + | − | − |
| WHI2 | XV/411309 | TCA-TAA | S147Stop | + | − | − |
| YLL066W-B | VIII/5683 | CCA-ACA | P27T | − | + | − |
| YRF1-6 | VIII/5871 | TTA-TCA | L27S | − | + | − |
| MMS2 | VII/346902 | ATG-ATT | M1I | − | − | + |
| HPF1 | VIII/31103 | GAA-GCA | E169A | − | − | + |
a
Nucleotide changes are indicated by underlining.