TABLE 2.
Anti-Toxoplasma activity of different doses of propranolol drug in brain and eye tissues in the acute phase (posttreatment group)
| Drug | Dose (mg/kg) | Brain |
Eye |
||
|---|---|---|---|---|---|
| CTa (mean parasite load) | P value | CT (mean parasite load) | P value | ||
| Propranolol | 2 | 21.14 ± 0.66 (612,623) | >0.05 | 24.70 ± 3.18 (227,979) | <0.001 |
| 3 | 21.17 ± 0.44 (870,668) | >0.05 | 22.86 ± 1.52 (428,559) | <0.001 | |
| Propranolol + pyrimethamine | 2 + 50 | 29.58 ± 0.5 (2,267) | <0.001 | 30.82 ± 3.17 (491) | <0.001 |
| 3 + 50 | 31.68 ± 3.76 (2,548) | <0.001 | 31.08 ± 2.58 (112.5) | <0.001 | |
| Pyrimethamine (positive control) | 50 | 30.62 ± 2.19 (1,741) | <0.001 | 32.03 ± 3.14 (3,577) | <0.001 |
| PBS (negative control) | 19.64 ± 1.88 (1,018,000) | 20.07 ± 1.22 (961,367) | |||
a
CT values are means ± SD.