TABLE 2.
Tigecycline resistance profile and list of identified mutations in the clinical A. baumannii isolate panel and the corresponding ΔadeR strains
| Strain designation | Tigecycline MIC (μg/ml) |
AdeRS amino acid substitution(s) | Deletion in trm | |
|---|---|---|---|---|
| Wild type | ΔadeR strain | |||
| ATCC-17978 | 0.4 | 0.4 | Reference | |
| BV26 | 6.3 | 0.4 | AdeS E201K E237K | |
| BV94 | 25 | 3.1 | AdeS F170S | G1065 |
| BV173 | 6.3 | 0.8 | AdeR D21V D26N | A240 |
| BV175 | 3.1 | 0.8 | A240 | |
| BV185 | 6.3 | 3.1 | A240 | |
| BV186 | 3.1 | 3.1 | G1065 | |
| BV187 | 3.1 | 3.1 | G1065 | |
| BV189 | 6.3 | 3.1 | A240 | |
| BV190 | 6.3 | 0.8 | AdeS Q339K | T1050 |
| BV191 | 25 | 1.6 | AdeS G79S | A240 |