Age (mean ± SD, range; yr) |
8.7 ± 4.6 (1–17) |
10.5 ± 6.6 (1–17) |
Gender (male:female) |
22:13 |
15:10 |
Weight (mean ± SD, range; kg) |
26.9 ± 14.0 (8.8–67.5) |
25.4 ± 16.2 (11.2–67.5) |
Duration of therapy (mean ± SD, range; days) |
11.9 ± 19.4 (1–41) |
15.5 ± 11.3 (9.5–41) |
Underlying diagnosis (no. of patients) |
|
|
Hematopoietic stem cell transplant |
|
|
Leukemia |
6 |
5 |
Sickle cell disease |
1 |
1 |
Aplastic anemia |
1 |
0 |
Chemotherapy |
|
|
Leukemia |
8 |
5 |
Lymphoma |
7 |
5 |
Solid tumor |
7 |
4 |
HIV |
4 |
4 |
Chronic granulomatous disease |
1 |
1 |
Clinical syndrome (no. of patients) |
|
|
Established infection |
6 |
6 |
Empirical treatment |
29 |
19 |
Pathogen (no. of patients) |
|
|
Candida albicans
|
2 |
2 |
Candida parapsilosis
|
1 |
1 |
Aspergillus fumigatus
|
3 |
3 |
Cryptosporidium
|
1 |
1 |
Clinical response (no. of patients) |
|
|
Success |
29 |
21 |
Failure |
8 |
4 |
Breakthrough |
1 |
0 |