TABLE 1.
Patient demographics of cohorts undergoing sampling on day one of therapy and at steady state
| Demographic | Value(s) |
|
|---|---|---|
| Day one (n = 35) | Steady state (n = 25) | |
| Age (mean ± SD, range; yr) | 8.7 ± 4.6 (1–17) | 10.5 ± 6.6 (1–17) |
| Gender (male:female) | 22:13 | 15:10 |
| Weight (mean ± SD, range; kg) | 26.9 ± 14.0 (8.8–67.5) | 25.4 ± 16.2 (11.2–67.5) |
| Duration of therapy (mean ± SD, range; days) | 11.9 ± 19.4 (1–41) | 15.5 ± 11.3 (9.5–41) |
| Underlying diagnosis (no. of patients) | ||
| Hematopoietic stem cell transplant | ||
| Leukemia | 6 | 5 |
| Sickle cell disease | 1 | 1 |
| Aplastic anemia | 1 | 0 |
| Chemotherapy | ||
| Leukemia | 8 | 5 |
| Lymphoma | 7 | 5 |
| Solid tumor | 7 | 4 |
| HIV | 4 | 4 |
| Chronic granulomatous disease | 1 | 1 |
| Clinical syndrome (no. of patients) | ||
| Established infection | 6 | 6 |
| Empirical treatment | 29 | 19 |
| Pathogen (no. of patients) | ||
| Candida albicans | 2 | 2 |
| Candida parapsilosis | 1 | 1 |
| Aspergillus fumigatus | 3 | 3 |
| Cryptosporidium | 1 | 1 |
| Clinical response (no. of patients) | ||
| Success | 29 | 21 |
| Failure | 8 | 4 |
| Breakthrough | 1 | 0 |