TABLE 2.
Parameter estimates for the final 2-compartment pharmacokinetic model
| Parameter and modela | Vin (liter) | Vfin (liter) | Kcp (h−1) | Kpc (h−1) | K (h−1) | CL (liter h−1 70 kg−1) |
|---|---|---|---|---|---|---|
| Base | ||||||
| Mean | 4.543 | NAb | 0.28 | 0.888 | NA | 0.488 |
| Median | 4.095 | NA | 0.184 | 0.254 | NA | 0.545 |
| SD | 3.44 | NA | 0.252 | 0.387 | NA | 0.29 |
| Error (CV) | 75.72 | NA | 90.025 | 43.581 | NA | 59.426 |
| Selected | ||||||
| Mean | 10.654 | 2.326 | 0.21 | 0.057 | 0.303 | 0.67 |
| Median | 7.998 | 2.986 | 0.178 | 0.033 | 0.027 | 0.665 |
| SD | 1.523 | 0.978 | 0.130 | 0.01 | 0.094 | 0.239 |
| Error (CV) | 14.295 | 42.064 | 61.905 | 17.544 | 31.023 | 35.672 |
a
CV, coefficient of variation.
b
NA, not applicable.