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. 2016 Jun 1;2(2):103–117. doi: 10.1089/aivt.2016.0011

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Copyright 2016, Mary Ann Liebert, Inc.

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FIG. 10. — Plots of the temporal readouts as displayed on the MPS-Db Study Summary page. After importing data into the MPS-Db, a graphical view of the results is provided for review and further analysis. In this study, there are five readouts (time in days). (A) Tolcapone at 220 μM induced cytochrome C release from mitochondria, a precursor to induction of apoptosis (T½ = 6.5 days), while at 88 μM tolcapone the signal was similar to the control. Entacapone at 40 μM and 16 μM showed only an accumulation or condensation of cytochrome C in the mitochondria. (B) Tolcapone (220 μM and 88 μM) induced a rapid reduction in urea production (BUN) over 2–7 days while entacapone did not significantly affect the urea. (C) Tolcapone (220 μM and 88 μM) induced a rapid loss of albumin secretion while entacapone had no effect. (D) Tolcapone (88 μM) completely blocked bile efflux. (E) Tolcapone (220 μM and 88 μM) induced rapid (2 day) release of LDH while entacapone induced LDH release only after about 12 days.