FIG. 5.

Comparison of selected adverse event data for entacapone and tolcapone. Plot of most frequent AEs in human liver, kidney, intestine, and brain. Solid bars, associated with the left axis, indicate the frequency of AEs relative to the frequency of use, while the light bars, associated with the right axis, indicate the number of AE reports. In the liver (the first three pairs of bars) the relative frequency of AE is much higher for tolcapone compared with entacapone, while for the other organs the frequencies are similar for tolcapone and entacapone. AE, adverse event.