Skip to main content
. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Front Biosci (Schol Ed). 2016 Jun 1;8:215–226. doi: 10.2741/s459

Figure 2.

Figure 2

AT2 Receptor signaling pathways: Ang II is converted to Ang III, the main ligand for the AT2 receptor. AT2 receptor signals primarily through the bradykinin-NO-cGMP and increases PGE2, a pronatriuresis prostaglandin. AT2 receptor also increases conversion of PGE2 to PGF2α, an antinatriuritic prostaglandin that also acts as an inhibitor of renin secretion. AT2 is known to activate phospholipase A2, increasing arachidonic acid release and conversion to downstream prostaglandins including PGI2.