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“Reproduced with permission from Siragy et.al.(80)”. Renal interstitial fluid PGE2 before and after intrarenal administration of the bradykinin antagonist icatibant (•) or vehicle (○) in uninephrectomized conscious dogs. PGE2 decreased during icatibant administration from 11.4.±0.4. pg/min during the control periods to 5.1.±0.3. during drug infusion (P<0.0.1).
