Table 2.
Types of infections by organ system and organ system for 246 patients (50 from derivation cohort and 196 from validation cohort)
| Index Severe Sepsis Case N=246 |
Types of Infections that occurred prior to ICU Admission* | ||
|---|---|---|---|
| Organ | Respiratory n (%) | 116 (47) | 36 (15) |
| Blood-stream n (%) | 65 (26) | 30 (12) | |
| Gastrointestinal n (%) | 17 (6.9) | 17 (6.9) | |
| Skin/Soft Tissue n (%) | 7 (2.9) | 9 (3.7) | |
| Genitourinary n (%) | 5 (2.0) | 4 (1.6) | |
| Other n (%) | 2 (0.8) | 0 (0) | |
| Undetermined n (%) | 34 (14) | 2 (0.81) | |
| None n (%) | n/a | 148 (60) | |
| Organism | S. aureus n (%) | 14 (5.7) | 4 (1.6) |
| Enterococcus sp n (%) | 9 (3.7) | 6 (2.4) | |
| Other gram positive bacterial n (%) | 24 (9.8) | 9 (3.7) | |
| Pseudomonas sp n (%) | 19 (7.7) | 3 (1.2) | |
| Klebsiella sp. n (%) | 7 (2.9) | 7 (2.8) | |
| E. coli n (%) | 7 (2.9) | 5(2.03 | |
| Other gram negative bacteria n (%) | 8 (3.3) | 4 (1.6) | |
| Polymicrobial bacterial n (%) | 11 (4.5) | 3 (1.2) | |
| Clostridium difficile n (%) | 11 (4.5) | 14 (5.7) | |
| Viral n (%) | 16 (6.5) | 10 (4.1) | |
| Fungal n (%) | 13 (5.3) | 13 (5.3) | |
| Mycobacterial n (%) | 1 (0.4) | 1 (0.41) | |
| Undetermined n (%) | 106 (43) | 19 (7.7) | |
| None n (%) | n/a | 148 (60) | |
*
98 patients had infections in the 90 days prior to admission for severe sepsis