Table 1.
Before therapy (n=8) | Ranolazine 2000 mg/day (one week) (n=8) | Ranolazine 2000 mg/day (last follow up)* (n=8) | |
---|---|---|---|
Resting QTc | 509 ± 41 | 452 ± 26† | 458 ± 10† |
Resting QRS | 96 ± 18 | 104 ± 20 | 106 ± 22 |
QTc at maximal QT-stretching | 536 ± 32 | 483 ± 24‡ | 483 ± 36† |
QTc at QT-stunning | 524 ± 56 | 454 ± 28 | 469 ± 23 |
Exercise QTc during sinus rate 100/min | 465 ± 12 | 457 ± 16 | 448 ± 21 |
Exercise QTc at maximal exercise | 446 ± 50 | 435 ± 48 | 435 ± 37 |
Exercise QTc at 1 min recovery | 449 ± 103 | 404 ± 35 | 436 ± 18 |
Exercise QTc at 5 min recovery | 465 ± 36 | 451 ± 31 | 458 ± 19 |
All values are presented in milliseconds.
Last follow-up denotes the last follow up on therapy, that is, without the values recorded after discontinuation of ranolazine in 3 patients (see text).
Denotes p <0.05 and
denotes p<0.005 in comparison to values before therapy.