Table 1.

Effects of ranolazine on the QT interval of LQT3 patients during provocative tests

	Before therapy (n=8)	Ranolazine 2000 mg/day (one week) (n=8)	Ranolazine 2000 mg/day (last follow up)* (n=8)
Resting QTc	509 ± 41	452 ± 26†	458 ± 10†
Resting QRS	96 ± 18	104 ± 20	106 ± 22
QTc at maximal QT-stretching	536 ± 32	483 ± 24‡	483 ± 36†
QTc at QT-stunning	524 ± 56	454 ± 28	469 ± 23
Exercise QTc during sinus rate 100/min	465 ± 12	457 ± 16	448 ± 21
Exercise QTc at maximal exercise	446 ± 50	435 ± 48	435 ± 37
Exercise QTc at 1 min recovery	449 ± 103	404 ± 35	436 ± 18
Exercise QTc at 5 min recovery	465 ± 36	451 ± 31	458 ± 19

All values are presented in milliseconds.

^*Last follow-up denotes the last follow up on therapy, that is, without the values recorded after discontinuation of ranolazine in 3 patients (see text).

^†Denotes p <0.05 and

^‡denotes p<0.005 in comparison to values before therapy.