Figure 1.

TbPSSA‐2 and TcISA ectodomains adopt a novel architecture and exhibit conformational flexibility. (A) Schematic representation of TbPSSA‐2 and TcISA with predicted structural domains, TM regions and signal peptides. (B) Secondary structure depictions of TbPSSA‐2 (left) and TcISA (right) highlighting lobe 1 (green) and lobe 2 (blue). The beta strand and the loop connecting the two lobes are shown in red. Four disulfide bonds in lobe 2 are shown as yellow ball and sticks. (C) Topology diagram of TbPSSA‐2 and TcISA colored as in (B). Rotational flexibility between lobes L1 and L2 in (D) TbPSSA‐2 (chain A‐pink; B‐dark teal) and (E) TcISA (chain A‐orange; B‐cyan; C‐limegreen; D‐marine). An interactive view is available in the electronic version of the article.