Table 3.

Reported Outcomes in Randomized Controlled Trials of Ibuprofen

	Medications, dose		Bleeding Incidence
Authors, Year	IB	KT	IB	KT	Result
Chen et al., 2009	400mg	T3	0	0	No significant difference in bleeding. Noted less pain on POD3 and any side effects with IB. More patients requesting to change medications with T3 vs IB (p = 0.045)
Mitchell et al., 2012	400mg	T3	2	3	No significant difference in bleeding, postop pain or incidence of adverse events. More patients requesting to change medications with T3 vs IB (p = 0.018).
Mixter et al., 1998	400mg	ketorolac	0	0	No significant difference in bleeding or pain.
Sniezek et al., 2011	Ac/IB, 1000/400mg	T3 or Ac	0	5	No bleeding complications noted in IB group. Noted significant difference between T3 vs IB for overall complication rate (p = 0.001)

IB, ibuprofen; KT, control; Ac, acetaminophen; T3, acetaminophen + codeine; POD3, postoperative day 3