Table 2.
ABO, H, Lewis and secretor histo-blood group systems, gene location, glycosyltransferases and synthesized carbohydrate structures of type 1 and type 2 precursor oligosaccharides.
| Systems | Genea | Chromosome location | Enzyme | Abbreviation | ECb | Nucleotide donor | Synthesized carbohydrate |
|---|---|---|---|---|---|---|---|
| H | FUT1 | 19q13.3 | α1,2-Fucosyltransferase | FUTI | 2.4.1.69 | GDP | H type 2 |
| Secretor | FUT2 | 19q13.3 | α1,2-Fucosyltransferase | FUTII | 2.4.1.69 | GDP | H type 1 |
| Lewis | FUT3 | 19p13.3 | α1,3/4-Fucosyltransferase | FUTIII | 2.4.1.65 | GDP | Lea, Leb, ALeb, BLeb |
| ABO | ABO | 9q.34.1 | α1,3-N-Acetylgalactosaminiltransferase | GTA | 2.4.1.40 | UDP | A type 1, A type 2 |
| α1,3-D-Galactosyltransferase | GTB | 2.4.1.37 | UDP | B type 1, B type 2 |
EC: Enzyme Commission Number; GDP: guanidine diphosphate; UDP: uridine diphosphate.
a
As stated by Human Genome Committee.
Source: Adapted from Schenkel-Brunner.23