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. 2016 Nov 20;22:4455–4474. doi: 10.12659/MSM.898091

Table 2.

Distribution of genotypes and alleles of the studied single-nucleotide polymorphism and the age of recurrent depression disorder onset.

Genotype/Allele Control (n=298) Early onset depression (n=130) Crude OR (95% CI) p Adjusted OR* (95% CI) p Late onset depression (n=128) Crude OR (95% CI) p Adjusted OR* (95% CI) p
N (Freq.) N (Freq.) N (Freq.)
c.-441G>A – FEN1 (rs174538)
 A/A 0 (−) 0 (−) – – – – 0 (–) – – – –
 A/G 151 (0.49) 59 (0.45) 0.88 (0.58–1.33) 0.544 0.88 (0.58–1.33) 0.549 50 (0.39) 0.68 (0.45–1.03) 0.070 0.68 (0.45–1.04) 0.073
 G/G 160 (0.51) 71 (0.55) 1.14 (0.75–1.71) 0.544 1.13 (0.75–1.71) 0.549 78 (0.61) 1.47 (0.97–2.24) 0.070 1.47 (0.96–2.23) 0.073
χ2=0.253; p=0.615 χ2=2.919; p=0.088
 A 151 (0.24) 59 (0.23) 0.88 (0.58–1.33) 0.544 0.88 (0.58–1.33) 0.549 50 (0.19) 0.68 (0.45–1.03) 0.070 0.68 (0.45–1.04) 0.073
 G 471 (0.76) 201 (0.77) 1.14 (0.75–1.71) 0.544 1.13 (0.75–1.71) 0.549 206 (0.81) 1.47 (0.97–2.24) 0.070 1.47 (0.96–2.23) 0.073
c.2285T>C – PARP1 (rs1136410)
 A/A 201 (0.65) 85 (0.65) 1.03 (0.67–1.59) 0.880 1.03 (0.67–1.58) 0.898 86 (0.67) 1.12 (0.72–1.73) 0.609 1.13 (0.73–1.75) 0.590
 A/G 103 (0.33) 39 (0.30) 0.86 (0.56–1.35) 0.523 0.87 (0.56–1.36) 0.542 35 (0.27) 0.76 (0.48–1.12) 0.237 0.75 (0.48–1.19) 0.219
 G/G 7 (0.02) 6 (0.05) 2.10 (0.69–6.38) 0.190 2.08 (0.68–6.31) 0.197 7 (0.06) 2.51 (0.86–7.31) 0.091 2.60 (0.89–7.60) 0.081
χ2=2.024; p=0.364 χ2=3.997; p=0.136
 A 505 (0.81) 209 (0.80) 0.95 (0.65–1.38) 0.776 0.94 (0.65–1.37) 0.766 207 (0.81) 0.98 (0.67–1.42) 0.908 0.98 (0.67–1.43) 0.914
 G 117 (0.19 51 (0.20) 1.06 (0.73–1.54) 0.776 1.06 (0.73–1.54) 0.766 49 (0.19) 1.02 (0.70–1.49) 0.908 1.02 (0.70–1.49) 0.914
c.580C>T – XRCC1 (rs1799782)
 G/G 274 (0.88) 108 (0.83) 0.66 (0.37–1.18) 0.159 0.67 (0.38–1.19) 0.174 110 (0.86) 0.83 (0.45–1.51) 0.534 0.79 (0.43–1.46) 0.459
 G/A 36 (0.12) 21 (0.16) 1.47 (0.82–2.63) 0.193 1.45 (0.81–2.61) 0.210 17 (0.13) 1.17 (063–2.17) 0.618 1.21 (0.65–2.26) 0.547
 A/A 1 (0.00) 1 (0.01) 2.40 (0.15–38.7) 0.536 2.41 (0.15–38.9) 0.535 1 (0.01) 2.44 (0.15–39.3) 0.529 2.71 (0.17–43.9) 0.484
χ2=2.159; p=0.334 χ2=0.688; p=0.709
 G 584 (0.94) 237 (0.91) 0.67 (0.39–1.15) 0.146 0.68 (0.39–1.17) 0.159 237 (0.93) 0.81 (0.46–1.44) 0.475 0.78 (0.44–1.39) 0.400
 A 38 (0.06) 23 (0.09) 1.49 (0.87–2.57) 0.146 1.48 (0.86–2.55) 0.159 19 (0.07) 1.23 (0.70–2.18) 0.475 1.28 (0.72–2.28) 0.400
c.1196A>G – XRCC1 (rs25487)
 C/C 130 (0.42) 52 (0.40) 0.93 (0.61–1.41) 0.736 0.92 (0.61–1.40) 0.706 50 (0.39) 0.89 (0.59–1.36) 0.596 0.91 (0.59–1.38) 0.642
 C/T 138 (0.44) 65 (0.50) 1.25 (0.83–1.89) 0.208 1.26 (0.84–1.90) 0.268 60 (0.47) 1.11 (0.73–1.67) 0.632 1.10 (0.73–1.66) 0.654
 T/T 43 (0.14) 13 (0.10) 0.69 (0.36–1.34) 0.273 0.69 (0.36–1.34) 0.273 18 (0.14) 1.02 (0.56–1.85) 0.948 1.01 (0.55–1.82) 0.987
χ2=1.760; p=0.415 χ2=0.295; p=0.863
 C 398 (0.64) 169 (0.65) 1.05 (0.77–1.42) 0.774 1.04 (0.77–1.41) 0.789 160 (0.63) 0.94 (0.70–1.27) 0.681 0.95 (0.70–1.28) 0.734
 T 224 (0.36) 91 (0.35) 0.96 (0.71–1.30) 0.774 0.96 (0.71–1.30) 0.789 96 (0.37) 1.06 (0.79–1.43) 0.681 1.05 (0.78–1.42) 0.734
c.*83A>C – LIG3 (rs4796030)
 A/A 31 (0.10) 28 (0.21) 2.48 (1.42–4.34) 0.001 2.48 (1.42–4.34) 0.001 24 (0.19) 2.08 (1.17–3.72) 0.013 2.06 (1.15–3.67) 0.015
 A/C 135 (0.43) 58 (0.45) 1.05 (0.69–1.59) 0.816 1.06 (0.70–1.60) 0.792 46 (0.36) 0.73 (0.48–1.12) 0.149 0.73 (0.47–1.11) 0.141
 C/C 145 (0.47) 44 (0.34) 0.59 (0.38–0.90) 0.014 0.58 (0.38–0.89) 0.013 58 (0.45) 0.95 (0.63–1.43) 0.802 0.96 (0.64–1.46) 0.851
χ2=12.697; p=0.002 χ2=6.844; p=0.033
 A 197 (0.32) 114 (0.44) 1.66 (1.23–2.23) <0.001 1.67 (1.24–2.24) <0.001 94 (0.37) 1.23 (0.92–1.66) 0.164 1.22 (0.91–1.65) 0.184
 C 425 (0.68) 146 (0.56) 0.60 (0.45–0.81) <0.001 0.60 (0.45–0.81) <0.001 162 (0.63) 0.81 (0.60–1.09) 0.164 0.82 (0.61–1.10) 0.184
c.*50C>T – LIG3 (rs1052536)
 C/C 56 (0.18) 40 (0.31) 2.02 (1.26–3.24) 0.003 2.02 (1.26–3.24) 0.003 32 (0.25) 1.52 (0.93–2.49) 0.098 1.53 (0.93–2.50) 0.094
 C/T 166 (0.53) 64 (0.49) 0.85 (0.56–1.28) 0.427 0.84 (0.56–1.27) 0.408 58 (0.55) 0.72 (0.48–1.09) 0.125 0.73 (0.48–1.10) 0.133
 T/T 89 (0.29) 26 (0.20) 0.62 (0.38–1.02) 0.062 0.63 (0.38–1.03) 0.066 38 (0.30) 1.05 (0.67–1.66) 0.822 1.04 (0.66–1.64) 0.863
χ2=9.773; p=0.008 χ2=3.404; p=0.182
 C 278 (0.45) 144 (0.55) 1.58 (1.16–2.13) 0.003 1.57 (1.16–2.13) 0.003 122 (0.48) 1.13 (0.84–1.52) 0.417 1.14 (0.85–1.53) 0.392
 T 344 (0.55) 116 (0.45) 0.64 (0.47–0.86) 0.003 0.64 (0.47–0.86) 0.003 134 (0.52) 0.88 (0.66–1.19) 0.417 0.88 (0.65–1.18) 0.392
c.-7C>T – LIG1 (rs20579)
 A/A 3 (0.01) 3 (0.02) 2.43 (0.48–12.2) 0.282 2.43 (0.48–12.2) 0.281 4 (0.03) 3.31 (0.73–15.0) 0.120 3.20 (0.70–14.6) 0.132
 A/G 73 (0.23) 25 (0.19) 0.78 (0.47–1.29) 0.329 0.78 (0.47–1.29) 0.328 32 (0.25) 1.09 (0.67–1.75) 0.733 1.09 (0.68–1.76) 0.718
 G/G 235 (0.76) 102 (0.79) 1.18 (0.72–1.93) 0.513 1.18 (0.72–1.93) 0.512 92 (0.72) 0.83 (0.52–1.32) 0.421 0.83 (0.52–1.31) 0.417
χ2=2.059; p=0.357 χ2=2.908; p=0.234
 A 79 (0.13) 31 (0.12) 0.93 (0.59–1.45) 0.748 0.93 (0.59–1.45) 0.747 40 (0.16) 1.28 (0.84–1.94) 0.246 1.28 (0.84–1.94) 0.249
 G 543 (0.87) 229 (0.88) 1.08 (0.69–1.68) 0.748 1.08 (0.69–1.68) 0.747 216 (0.84) 0.78 (0.52–1.19) 0.246 0.78 (0.52–1.19) 0.249
c.-468T>G – APEX1 (rs1760944)
 T/T 56 (0.18) 16 (0.12) 0.64 (0.35–1.16) 0.142 0.64 (0.35–1.16) 0.137 29 (0.23) 1.33 (0.81–2.21) 0.263 1.34 (0.81–2.23) 0.254
 T/G 142 (0.46) 73 (0.56) 1.52 (1.01–2.30) 0.045 1.52 (1.01–2.29) 0.047 66 (0.52) 1.27 (0.84–1.91) 0.261 1.27 (0.84–1.92) 0.253
 G/G 113 (0.36) 41 (0.32) 0.81 (0.52–1.25) 0.336 0.81 (0.53–1.26) 0.353 33 (0.26) 0.61 (0.39–0.96) 0.034 0.60 (0.38–0.95) 0.031
χ2=2.908; p=0.234 χ2=4.716; p=0.095
 T 254 (0.41) 105 (0.40) 0.98 (0.73–1.32) 0.900 0.98 (0.73–1.31) 0.872 124 (0.48) 1.35 (1.01–1.80) 0.043 1.36 (1.01–1.82) 0.039
 G 368 (0.59) 155 (0.60) 1.02 (0.76–1.37) 0.900 1.03 (0.76–1.38) 0.872 132 (0.52 0.74 (0.56–0.99) 0.043 0.74 (0.55–0.98) 0.039
c.444T>G – APEX1 (rs1130409)
 G/G 71 (0.23) 27 (0.21) 0.89 (0.54–1.46) 0.635 0.89 (0.54–1.48) 0.664 33 (0.26) 1.17 (0.73–1.89) 0.509 1.17 (0.73–1.89) 0.517
 G/T 164 (0.53) 68 (0.52) 0.98 (0.65–1.48) 0.935 0.98 (0.65–1.47) 0.914 66 (0.51) 0.95 (0.63–1.44) 0.823 0.96 (0.64–1.45) 0.844
 T/T 76 (0.24) 35 (0.27) 1.14 (0.72–1.82) 0.584 1.14 (0.71–1.81) 0.590 29 (0.23) 0.91 (0.55–1.48) 0.691 0.90 (0.55–1.47) 0.677
χ2=0.403; p=0.817 χ2=0.477; p=0.788
 G 306 (0.49) 122 (0.47) 0.91 (0.67–1.22) 0.527 0.91 (0.68–1.23) 0.547 132 (0.52) 1.11 (0.82–1.49) 0.514 1.11 (0.82–1.49) 0.512
 T 316 (0.51) 138 (0.53) 1.10 (0.82–1.48) 0.527 1.10 (0.81–1.48) 0.547 124 (0.48) 0.91 (0.67–1.22) 0.514 0.91 (0.67–1.22) 0.512

Early onset depression – the first episode occurred at or before 35 years of age. Late onset depression – the first episode occurred after 35 years of age.

*

OR adjusted for sex. p<0.050 along with corresponding ORs are in bold; p<0.012 along with corresponding ORs are in bold and italic.