Table 3.
Gene-gene interactions of the studied polymorphisms and the risk of rDD.
| Combined genotype | Control (n=311) | Depression (n=288) | Crude OR (95% CI) | p | Adjusted OR* (95% CI) | p | ||
|---|---|---|---|---|---|---|---|---|
| Number | Frequency | Number | Frequency | |||||
| c.444T>G – APEX1 (rs1130409) and c.1196A>G – XRCC1 (rs25487) | ||||||||
| G/T-C/C | 75 | 0.241 | 48 | 0.167 | 0.629 (0.420–0.943) | 0.025 | 0.627 (0.418–0.940) | 0.024 |
| G/T-C/T | 68 | 0.219 | 88 | 0.306 | 1.572 (1.089–2.271) | 0.016 | 1.573 (1.089–2.272) | 0.016 |
| c.-468T>G – APEX1 (rs1760944) and c.*50C>T – LIG3 (rs1052536) | ||||||||
| G/G-C/T | 66 | 0.212 | 37 | 0.128 | 0.547 (0.353–0.849) | 0.007 | 0.547 (0.353–0.850) | 0.007 |
| c.-468T>G – APEX1 (rs1760944) and c.*83A>C – LIG3 (rs4796030)0 | ||||||||
| G/G-A/C | 53 | 0.170 | 28 | 0.097 | 0.524 (0.321–0.855) | 0.010 | 0.524 (0.321–0.856) | 0.010 |
| c.-468T>G – APEX1 (rs1760944) and c.580C>T – XRCC1 (rs1799782) | ||||||||
| G/G-G/G | 99 | 0.318 | 69 | 0.240 | 0.675 (0.470–0.968) | 0.033 | 0.675 (0.470–0.969) | 0.033 |
| c.-468T>G – APEX1 (rs1760944) and c.1196A>G – XRCC1 (rs25487) | ||||||||
| T/G-C/T | 62 | 0.199 | 80 | 0.278 | 1.545 (1.057–2.257) | 0.025 | 1.546 (1.058–2.260) | 0.024 |
| c.-468T>G – APEX1 (rs1760944) and c.-441G>A – FEN1 (rs174538) | ||||||||
| T/G-G/G | 75 | 0.241 | 93 | 0.323 | 1.501 (1.049–2.148) | 0.026 | 1.500 (1.048–2.148) | 0.027 |
| G/G-A/G | 55 | 0.177 | 32 | 0.111 | 0.582 (0.364–0.930) | 0.024 | 0.582 (0.364–0.931) | 0.024 |
| c.-7C>T – LIG1 (rs20579) and c.*50C>T – LIG3 (rs1052536) | ||||||||
| G/G-C/C | 44 | 0.141 | 59 | 0.205 | 1.563 (1.019–2.400) | 0.041 | 1.564 (1.019–2.400) | 0.041 |
| c.-7C>T – LIG1 (rs20579) and c.*83A>C – LIG3 (rs4796030) | ||||||||
| G/G-A/A | 25 | 0.080 | 40 | 0.139 | 1.845 (1.088–3.128) | 0.023 | 1.851 (1.091–3.139) | 0.022 |
| c.-7C>T – LIG1 (rs20579) and c.-441G>A – FEN1 (rs174538) | ||||||||
| A/G-A/G | 37 | 0.119 | 19 | 0.066 | 0.523 (0.293–0.933) | 0.028 | 0.523 (0.293–0.932) | 0.028 |
| c.*50C>T – LIG3 (rs1052536) and c.580C>T – XRCC1 (rs1799782) | ||||||||
| C/C-G/G | 47 | 0.151 | 63 | 0.219 | 1.573 (1.036–2.388) | 0.034 | 1.572 (1.036–2.387) | 0.034 |
| c.*50C>T – LIG3 (rs1052536) and c.2285T>C – PARP1 (rs1136410) | ||||||||
| C/C-A/A | 39 | 0.125 | 57 | 0.198 | 1.721 (1.105–2.681) | 0.016 | 1.720 (1.104–2.681) | 0.017 |
| c.*50C>T – LIG3 (rs1052536) and c.-441G>A – FEN1 (rs174538) | ||||||||
| C/C-G/G | 27 | 0.087 | 48 | 0.167 | 2.104 (1.274–3.475) | 0.004 | 2.104 (1.274–3.475) | 0.004 |
| C/T-A/G | 86 | 0.277 | 58 | 0.201 | 0.660 (0.451–0.965) | 0.032 | 0.658 (0.449–0.963) | 0.031 |
| c.*83A>C – LIG3 (rs4796030) and c.580C>T – XRCC1 (rs1799782) | ||||||||
| A/A-G/G | 25 | 0.080 | 43 | 0.149 | 2.008 (1.192–3.383) | 0.009 | 2.015 (1.195–3.398) | 0.009 |
| c.*83A>C – LIG3 (rs4796030) and c.1196A>G – XRCC1 (rs25487) | ||||||||
| A/A-C/T | 13 | 0.042 | 27 | 0.094 | 2.371 (1.199–4.691) | 0.013 | 2.374 (1.200–4.698) | 0.013 |
| c.*83A>C – LIG3 (rs4796030) and c.2285T>C – PARP1 (rs1136410) | ||||||||
| A/A-A/A | 19 | 0.061 | 37 | 0.128 | 2.265 (1.271–4.039) | 0.006 | 2.268 (1.272–4.044) | 0.006 |
| C/C-A/G | 54 | 0.174 | 31 | 0.108 | 0.574 (0.357–0.922) | 0.022 | 0.574 (0.357–0.922) | 0.022 |
| c.*83A>C – LIG3 (rs4796030) and c.-441G>A – FEN1 (rs174538) | ||||||||
| A/A-G/G | 13 | 0.042 | 35 | 0.122 | 3.171 (1.642–6.125) | < 0.001 | 3.171 (1.642–6.124) | <0.001 |
| c.580C>T – XRCC1 (rs1799782) and c.-441G>A – FEN1 (rs174538) | ||||||||
| G/G-A/G | 135 | 0.434 | 101 | 0.351 | 0.704 (0.506–0.979) | 0.037 | 0.704 (0.506–0.979) | 0.037 |
| c.1196A>G – XRCC1 (rs25487) and c.2285T>C – PARP1 (rs1136410) | ||||||||
| C/T-G/G | 3 | 0.010 | 10 | 0.035 | 3.693 (1.006–13.556) | 0.049 | 3.691 (1.006–13.549) | 0.049 |
| c.2285T>C – PARP1 (rs1136410) and c.-441G>A – FEN1 (rs174538) | ||||||||
| G/G-G/G | 3 | 0.010 | 10 | 0.035 | 3.693 (1.006–13.556) | 0.049 | 3.699 (1.007–13.578) | 0.049 |
*
OR adjusted for sex. p<0.05 along with corresponding ORs are in bold; p<0.012 along with corresponding ORs are in bold and italic.