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. 2016 Nov 20;22:4455–4474. doi: 10.12659/MSM.898091

Supplementary Table 1.

Gene-gene interactions of the studied polymorphisms and the risk of rDD.

Combined genotype Control (n=311) Depression (n=288) Crude OR (95% CI) p Adjusted OR* (95% CI) p
Number Frequency Number Frequency
c.444T>G – APEX1 (rs1130409) and c.-7C>T – LIG1 (rs20579)
G/G-A/A 0 - 1 0.003 – – – –
G/G-A/G 20 0.064 18 0.063 0.970 (0.502–1.873) 0.928 0.970 (0.502–1.873) 0.928
G/G-G/G 51 0.164 45 0.156 0.944 (0.610–1.462) 0.797 0.945 (0.610–1.464) 0.800
G/T-A/A 2 0.006 5 0.017 2.730 (0.525–14.181) 0.232 2.771 (0.531–14.459) 0.227
G/T-A/G 44 0.141 33 0.115 0.785 (0.485–1.273) 0.327 0.785 (0.484–1.272) 0.326
G/T-G/G 118 0.379 112 0.389 1.041 (0.749–1.447) 0.812 1.040 (0.748–1.446) 0.817
T/T-A/A 1 0.003 1 0.003 1.080 (0.067–17.349) 0.957 1.068 (0.066–17.231) 0.963
T/T-A/G 9 0.029 14 0.049 1.715 (0.730–4.024) 0.216 1.713 (0.730–4.021) 0.217
T/T-G/G 66 0.212 59 0.205 0.956 (0.645–1.419) 0.825 0.957 (0.645–1.420) 0.827
c.444T>G – APEX1 (rs1130409) and c.*50C>T – LIG3 (rs1052536)
G/G-C/C 13 0.042 16 0.056 1.348 (0.637–2.855) 0.435 1.348 (0.637–2.854) 0.435
G/G-C/T 35 0.113 26 0.090 0.783 (0.458–1.336) 0.369 0.783 (0.459–1.337) 0.370
G/G-T/T 23 0.074 22 0.076 1.036 (0.564–1.902) 0.910 1.037 (0.565–1.906) 0.906
G/T-C/C 30 0.096 40 0.139 1.511 (0.913–2.499) 0.108 1.510 (0.912–2.498) 0.109
G/T-C/T 91 0.293 76 0.264 0.867 (0.606–1.240) 0.434 0.866 (0.605–1.240) 0.433
G/T-T/T 43 0.138 34 0.118 0.834 (0.515–1.350) 0.461 0.834 (0.516–1.350) 0.461
T/T-C/C 13 0.042 23 0.080 1.990 (0.988–4.006) 0.054 1.994 (0.990–4.018) 0.053
T/T-C/T 40 0.129 34 0.118 0.907 (0.557–1.478) 0.695 0.905 (0.555–1.476) 0.690
T/T-T/T 23 0.074 17 0.059 0.785 (0.411–1.502) 0.466 0.786 (0.411–1.505) 0.468
c.444T>G – APEX1 (rs1130409) and c.*83A>C – LIG3 (rs4796030)
G/G-A/A 5 0.016 12 0.042 2.661 (0.926–7.649) 0.069 2.658 (0.924–7.642) 0.070
G/G-A/C 32 0.103 26 0.090 0.865 (0.502–1.491) 0.602 0.866 (0.503–1.494) 0.606
G/G-C/C 34 0.109 26 0.090 0.808 (0.472–1.384) 0.439 0.809 (0.472–1.385) 0.440
G/T-A/A 17 0.055 27 0.094 1.789 (0.953–3.357) 0.070 1.790 (0.954–3.358) 0.070
G/T-A/C 70 0.225 64 0.222 0.984 (0.670–1.445) 0.933 0.984 (0.670–1.447) 0.936
G/T-C/C 77 0.248 59 0.205 0.783 (0.533–1.151) 0.213 0.781 (0.531–1.148) 0.208
T/T-A/A 9 0.029 14 0.049 1.715 (0.730–4.024) 0.216 1.730 (0.735–4.072) 0.210
T/T-A/C 33 0.106 30 0.104 0.980 (0.581–1.652) 0.938 0.979 (0.580–1.651) 0.936
T/T-C/C 34 0.109 30 0.104 0.947 (0.564–1.593) 0.838 0.946 (0.563–1.591) 0.835
c.444T>G – APEX1 (rs1130409) and c.580C>T – XRCC1 (rs1799782)
G/G-G/G 62 0.199 51 0.177 0.864 (0.573–1.304) 0.784 0.865 (0.573–1.306) 0.491
G/G-G/A 9 0.029 13 0.045 1.586 (0.668–3.769) 0.296 1.583 (0.666–3.766) 0.299
G/G-A/A 0 – 0 – – – – –
G/T-G/G 142 0.457 130 0.451 0.979 (0.710–1.351) 0.898 0.979 (0.710–1.351) 0.899
G/T-G/A 22 0.071 19 0.066 0.928 (0.491–1.752) 0.817 0.925 (0.489–1.749) 0.810
G/T-A/A 0 – 1 0.003 – – – –
T/T-G/G 70 0.225 63 0.219 0.964 (0.655–1.418) 0.852 0.964 (0.656–1.419) 0.854
T/T-G/A 5 0.016 10 0.035 2.201 (0.743–6.520) 0.154 2.198 (0.742–6.512) 0.155
T/T-A/A 1 0.003 1 0.003 1.080 (0.067–17.349) 0.957 1.080 (0.067–17.354) 0.956
c.444T>G – APEX1 (rs1130409) and c.1196A>G – XRCC1 (rs25487)
G/G-C/C 28 0.090 30 0.104 1.175 (0.684–2.021) 0.559 1.177 (0.684–2.024) 0.556
G/G-C/T 36 0.116 27 0.094 0.790 (0.467–1.338) 0.381 0.791 (0.467–1.339) 0.382
G/G-T/T 7 0.023 7 0.024 1.082 (0.375–3.123) 0.884 1.082 (0.375–3.124) 0.884
G/T-C/C 75 0.241 48 0.167 0.629 (0.420–0.943) 0.025 0.627 (0.418–0.940) 0.024
G/T-C/T 68 0.219 88 0.306 1.572 (1.089–2.271) 0.016 1.573 (1.089–2.272) 0.016
G/T-T/T 21 0.068 14 0.049 0.706 (0.352–1.415) 0.326 0.706 (0.352–1.417) 0.328
T/T-C/C 27 0.087 30 0.104 1.223 (0.708–2.113) 0.470 1.222 (0.707–2.111) 0.472
T/T-C/T 34 0.109 30 0.104 0.947 (0.564–1.593) 0.838 0.948 (0.564–1.594 0.840
T/T-T/T 15 0.048 14 0.049 1.008 (0.478–2.127) 0.983 1.009 (0.478–2.129) 0.981
c.444T>G – APEX1 (rs1130409) and c.2285T>C – PARP1 (rs1136410)
G/G-A/A 44 0.141 48 0.167 1.214 (0.778–1.893) 0.393 1.214 (0.778–1.893) 0.393
G/G-A/G 25 0.080 16 0.056 0.673 (0.352–1.288) 0.232 0.674 (0.352–1.291) 0.234
G/G-G/G 2 0.006 0 – – – – –
G/T-A/A 104 0.334 96 0.33 0.995 (0.708–1.398) 0.978 0.993 (0.706–1.397) 0.967
G/T-A/G 57 0.183 46 0.160 0.847 (0.553–1.298) 0.446 0.848 (0.553–1.301) 0.450
G/T-G/G 3 0.010 8 0.028 2.933 (0.771–11.166) 0.115 2.938 (0.772–11.186) 0.114
T/T-A/A 53 0.170 47 0.163 0.949 (0.617–1.460) 0.813 0.950 (0.618–1.461) 0.816
T/T-A/G 21 0.068 20 0.069 1.031 (0.546–1.944) 0.926 1.029 (0.546–1.942) 0.929
T/T-G/G 2 0.006 7 0.024 3.849 (0.793–18.681) 0.094 3.845 (0.792–18.666) 0.095
c.444T>G – APEX1 (rs1130409) and c.-441G>A – FEN1 (rs174538)
G/G-A/A 0 – 0 - – – – –
G/G-A/G 38 0.122 24 0.083 0.653 (0.381–1.119) 0.121 0.653 (0.381–1.119) 0.121
G/G-G/G 33 0.106 40 0.139 1.359 (0.831–2.222) 0.222 1.361 (0.832–2.226) 0.220
G/T-A/A 0 – 2 – – – – –
G/T-A/G 75 0.241 61 0.212 0.846 (0.576–1.241) 0.392 0.845 (0.575–1.240) 0.389
G/T-G/G 89 0.286 89 0.309 1.116 (0.786–1.584) 0.541 1.115 (0.785–1.584) 0.542
T/T-A/A 0 – 0 – – – – –
T/T-A/G 38 0.122 34 0.118 0.962 (0.587–1.575) 0.877 0.692 (0.587–1.575) 0.877
T/T-G/G 38 0.122 40 0.139 1.159 (0.720–1.865) 0.544 1.159 (0.720–1.865) 0.544
c.-468T>G – APEX1 (rs1760944) and c.-7C>T – LIG1 (rs20579)
T/T-A/A 1 0.003 1 0.003 1.080 (0.067–17.349) 0.957 1.080 (0.067–17.354) 0.956
T/T-A/G 11 0.035 11 0.038 1.083 (0.462–2.538) 0.854 1.086 (0.463–2.546) 0.850
T/T-G/G 44 0.141 36 0.125 0.867 (0.540–1.391) 0.554 0.865 (0.539–1.389) 0.550
T/G-A/A 2 0.006 4 0.014 2.176 (0.396–11.971) 0.371 2.187 (0.397–12.046) 0.369
T/G-A/G 32 0.103 33 0.115 1.128 (0.674–1.888) 0.646 1.128 (0.674–1.888) 0.647
T/G-G/G 108 0.347 120 0.417 1.343 (0.965–1.869) 0.081 0.856 (0.614–1.192) 0.356
G/G-A/A 0 - 2 0.007 – – – –
G/G-A/G 30 0.096 21 0.073 0.737 (0.412–1.319) 0.304 0.735 (0.411–1.317) 0.301
G/G-G/G 83 0.267 60 0.208 0.723 (0.495–1.057) 0.094 0.723 (0.494–1.058) 0.095
c.-468T>G – APEX1 (rs1760944) and c.*50C>T – LIG3 (rs1052536)
T/T-C/C 12 0.039 19 0.066 1.760 (0.839–3.693) 0.135 1.759 (0.838–3.691) 0.136
T/T-C/T 25 0.080 18 0.063 0.763 (0.407–1.430) 0.398 0.760 (0.405–1.426) 0.392
T/T-T/T 19 0.061 11 0.038 0.610 (0.285–1.306) 0.203 0.611 (0.285–1.310) 0.205
T/G-C/C 28 0.090 39 0.125 1.444 (0.857–2.434) 0.168 1.443 (0.855–2.433) 0.169
T/G-C/T 75 0.241 81 0.281 1.231 (0.854–1.774) 0.264 1.231 (0.854–1.774) 0.265
T/G-T/T 39 0.125 40 0.139 1.125 (0.701–1.806) 0.626 1.021 (0.636–1.639) 0.931
G/G-C/C 16 0.051 24 0.083 1.676 (0.872–3.224) 0.122 1.682 (0.874–3.237) 0.120
G/G-C/T 66 0.212 37 0.128 0.547 (0.353–0.849) 0.007 0.547 (0.353–0.850) 0.007
G/G-T/T 31 0.100 22 0.076 0.747 (0.422–1.323) 0.317 0.747 (0.422–1.324) 0.318
c.-468T>G – APEX1 (rs1760944) and c.*83A>C – LIG3 (rs4796030)0
T/T-A/A 4 0.013 10 0.035 2.761 (0.856–8.903) 0.089 2.768 (0.858–8.930) 0.088
T/T-A/C 18 0.058 18 0.063 1.085 (0.553–2.129) 0.812 1.083 (0.552–2.126) 0.816
T/T-C/C 34 0.109 20 0.069 0.608 (0.341–1.083) 0.091 0.608 (0.341–1.083) 0.091
T/G-A/A 17 0.055 24 0.083 1.572 (0.826–2.991) 0.168 1.572 (0.826–2.991) 0.168
T/G-A/C 64 0.206 74 0.257 1.335 (0.911–1.954) 0.138 1.335 (0.912–1.955) 0.138
T/G-C/C 61 0.196 59 0.205 1.056 (0.708–1.576) 0.790 1.054 (0.706–1.574) 0.796
G/G-A/A 10 0.032 19 0.066 2.126 (0.971–4.653) 0.059 2.134 (0.975–4.674) 0.058
G/G-A/C 53 0.170 28 0.097 0.524 (0.321–0.855) 0.010 0.524 (0.321–0.856) 0.010
G/G-C/C 50 0.161 36 0.125 0.746 (0.470–1.184) 0.213 0.745 (0.469–1.183) 0.212
c.-468T>G – APEX1 (rs1760944) and c.580C>T – XRCC1 (rs1799782)
T/T-G/G 45 0.145 41 0.142 0.981 (0.621–1.550) 0.935 0.982 (0.621–1.551) 0.937
T/T-G/A 10 0.032 7 0.024 0.750 (0.282–1.997) 0.565 0.745 (0.279–1.989) 0.557
T/T-A/A 1 0.003 0 – – – – –
T/G-G/G 130 0.418 134 0.465 1.211 (0.877–1.674) 0.244 1.211 (0.877–1.673) 0.245
T/G-G/A 12 0.039 21 0.073 1.960 (0.946–4.059) 0.070 1.958 (0.945–4.058) 0.071
T/G-A/A 0 – 2 0.007 – – – –
G/G-G/G 99 0.318 69 0.240 0.675 (0.470–0.968) 0.033 0.675 (0.470–0.969) 0.033
G/G-G/A 14 0.045 14 0.049 1.084 (0.508–2.315) 0.835 1.082 (0.506–2.311) 0.840
G/G-A/A 0 – 0 – – – – –
c.-468T>G – APEX1 (rs1760944) and c.1196A>G – XRCC1 (rs25487)
T/T-C/C 27 0.087 19 0.066 0.743 (0.404–1.368) 0.340 0.741 (0.402–1.365) 0.336
T/T-C/T 25 0.080 23 0.080 0.993 (0.550–1.792) 0.981 0.993 (0.550–1.792) 0.982
T/T-T/T 4 0.013 6 0.021 1.633 (0.456–5.847) 0.451 1.638 (0.457–5.868) 0.448
T/G-C/C 58 0.186 57 0.198 1.076 (0.717–1.617) 0.723 1.075 (0.715–1.615) 0.728
T/G-C/T 62 0.199 80 0.278 1.545 (1.057–2.257) 0.025 1.546 (1.058–2.260) 0.024
T/G-T/T 22 0.071 20 0.069 0.980 (0.523–1.837) 0.951 0.979 (0.522–1.835) 0.947
G/G-C/C 45 0.145 32 0.111 0.739 (0.455–1.200) 0.221 0.739 (0.455–1.201) 0.222
G/G-C/T 51 0.164 42 0.146 0.870 (0.558–1.357) 0.540 0.871 (0.558–1.357) 0.541
G/G-T/T 17 0.055 9 0.031 0.558 (0.245–1.272) 0.165 0.559 (0.244–1.276) 0.167
c.-468T>G – APEX1 (rs1760944) and c.2285T>C – PARP1 (rs1136410)
T/T-A/A 31 0.100 29 0.101 1.011 (0.593–1.725) 0.967 1.011 (0.593–1.724) 0.969
T/T-A/G 23 0.074 16 0.056 0.737 (0.381–1.424) 0.363 0.736 (0.381–1.423) 0.362
T/T-G/G 2 0.006 3 0.010 1.626 (0.270–9.803) 0.596 1.631 (0.270–9.835) 0.594
T/G-A/A 96 0.309 105 0.365 1.285 (0.915–1.805) 0.148 1.285 (0.913–1.808) 0.150
T/G-A/G 44 0.141 45 0.156 1.124 (0.716–1.763) 0.612 1.128 (0.718–1.772) 0.603
T/G-G/G 2 0.006 7 0.024 3.849 (0.793–18.681) 0.094 3.845 (0.792–18.666) 0.095
G/G-A/A 74 0.238 57 0.198 0.790 (0.535–1.167) 0.237 0.791 (0.535–1.169) 0.239
G/G-A/G 36 0.116 21 0.073 0.601 (0.342–1.056) 0.077 0.601 (0.342–1.057) 0.077
G/G-G/G 3 0.010 5 0.017 1.814 (0.430–7.659) 0.418 1.810 (0.428–7.645) 0.420
c.-468T>G – APEX1 (rs1760944) and c.-441G>A – FEN1 (rs174538)
T/T-A/A 0 – 0 – – – – –
T/T-A/G 29 0.093 23 0.080 0.844 (0.476–1.496) 0.561 0.838 (0.471–1.491) 0.548
T/T-G/G 27 0.087 25 0.087 1.000 (0.566–1.767) 1.000 1.004 (0.567–1.777) 0.990
T/G-A/A 0 – 0 – – – – –
T/G-A/G 67 0.215 64 0.222 1.041 (0.706–1.533) 0.841 1.041 (0.706–1.534) 0.840
T/G-G/G 75 0.241 93 0.323 1.501 (1.049–2.148) 0.026 1.500 (1.048–2.148) 0.027
G/G-A/A 0 – 0 – – – – –
G/G-A/G 55 0.177 32 0.111 0.582 (0.364–0.930) 0.024 0.582 (0.364–0.931) 0.024
G/G-G/G 58 0.186 51 0.177 0.939 (0.619–1.423) 0.765 0.939 (0.619–1.423) 0.766
c.-7C>T – LIG1 (rs20579) and c.*50C>T – LIG3 (rs1052536)
A/A-C/C 0 – 0 – – – – –
A/A-C/T 2 0.006 4 0.014 2.176 (0.396–11.971) 0.371 2.187 (0.397–12.046) 0.369
A/A-T/T 1 0.003 3 0.010 3.263 (0.338–31.550) 0.307 3.264 (0.338–31.560) 0.307
A/G-C/C 12 0.039 20 0.069 1.859 (0.892–3.876) 0.098 1.858 (0.891–3.873) 0.098
A/G-C/T 42 0.135 31 0.108 0.773 (0.471–1.267) 0.306 0.773 (0.471–1.267) 0.307
A/G-T/T 19 0.061 14 0.049 0.785 (0.386–1.597) 0.504 0.785 (0.386–1.597) 0.504
G/G-C/C 44 0.141 59 0.205 1.563 (1.019–2.400) 0.041 1.564 (1.019–2.400) 0.041
G/G-C/T 122 0.392 101 0.351 0.837 (0.600–1.166) 0.293 0.836 (0.599–1.165) 0.290
G/G-T/T 69 0.222 56 0.194 0.847 (0.570–1.258) 0.410 0.847 (0.570–1.260) 0.413
c.-7C>T – LIG1 (rs20579) and c.*83A>C – LIG3 (rs4796030)
A/A-A/A 0 – 0 – – –
A/A-A/C 0 – 2 0.007 – –
A/A-C/C 3 0.010 5 0.017 1.814 (0.430–7.659) 0.418 1.821 (0.431–7.694) 0.415
A/G-A/A 6 0.019 13 0.045 2.403 (0.901–6.409) 0.080 2.402 (0.901–6.407) 0.080
A/G-A/C 34 0.109 25 0.087 0.774 (0.450–1.333) 0.356 0.775 (0.450–1.335) 0.359
A/G-C/C 33 0.106 27 0.094 0.871 (0.510–1.489) 0.615 0.870 (0.508–1.487) 0.610
G/G-A/A 25 0.080 40 0.139 1.845 (1.088–3.128) 0.023 1.851 (1.091–3.139) 0.022
G/G-A/C 101 0.325 93 0.323 0.992 (0.704–1.397) 0.962 0.992 (0.704–1.397) 0.963
G/G-C/C 109 0.350 83 0.288 0.750 (0.531–1.060) 0.103 0.749 (0.530–1.059) 0.101
c.-7C>T – LIG1 (rs20579) and c.2285T>C – PARP1 (rs1136410)
A/A-A/A 1 0.003 2 0.007 2.168 (0.196–24.036) 0.528 2.151 (0.193–23.970) 0.534
A/A-A/G 2 0.006 4 0.014 2.176 (0.396–11.971) 0.371 2.202 (0.399–12.159) 0.365
A/A-G/G 0 – 1 0.003 – – – –
A/G-A/A 49 0.158 46 0.160 1.016 (0.655–1.576) 0.942 1.016 (0.655–1.575) 0.945
A/G-A/G 24 0.077 17 0.059 0.750 (0.394–1.427) 0.381 0.751 (0.395–1.428) 0.382
A/G-G/G 0 – 2 0.007 – – – –
G/G-A/A 151 0.486 143 0.497 1.045 (0.758–1.440) 0.788 1.044 (0.758–1.439) 0.792
G/G-A/G 77 0.248 61 0.212 0.817 (0.557–1.197) 0.299 0.817 (0.557–1.199) 0.302
G/G-G/G 7 0.023 12 0.042 1.888 (0.733–4.864) 0.188 1.886 (0.732–4.859) 0.189
c.-7C>T – LIG1 (rs20579) and c.-441G>A – FEN1 (rs174538)
A/A-A/A 0 – 0 – – – – –
A/A-A/G 2 0.006 5 0.017 2.730 (0.525–14.181) 0.232 2.730 (0.525–14.181) 0.232
A/A-G/G 1 0.003 2 0.007 2.168 (0.196–24.036) 0.528 2.161 (0.195–23.970) 0.530
A/G-A/A 0 – 0 – – – – –
A/G-A/G 37 0.119 19 0.066 0.523 (0.293–0.933) 0.028 0.523 (0.293–0.932) 0.028
A/G-G/G 36 0.116 46 0.160 1.452 (0.908–2.321) 0.119 1.452 (0.908–2.321) 0.119
G/G-A/A 0 – 0 – – – – –
G/G-A/G 112 0.360 95 0.330 0.875 (0.624–1.226) 0.437 0.874 (0.624–1.225) 0.435
G/G-C/C 123 0.395 121 0.420 1.107 (0.799–1.535) 0.540 1.108 (0.800–1.535) 0.538
c.*50C>T – LIG3 (rs1052536) and c.580C>T – XRCC1 (rs1799782)
C/C-G/G 47 0.151 63 0.219 1.573 (1.036–2.388) 0.034 1.572 (1.036–2.387) 0.034
C/C-G/A 9 0.029 14 0.049 1.715 (0.730–4.024) 0.216 1.714 (0.730–4.023) 0.216
C/C-A/A 0 - 2 0.007 – – – –
C/T-G/G 152 0.489 122 0.424 0.769 (0.557–1.061) 0.110 0.769 (0.557–1.062) 0.110
C/T-G/A 13 0.042 14 0.049 1.171 (0.541–2.536) 0.688 1.167 (0.5358–2.534) 0.696
C/T-A/A 1 0.003 0 – – – – –
T/T-G/G 75 0.241 59 0.205 0.811 (0.551–1.193) 0.287 0.811 (0.551–1.196) 0.291
T/T-G/A 14 0.045 14 0.049 1.084 (0.508–2.315) 0.835 1.081 (0.505–2.311) 0.841
T/T-A/A 0 – 0 – – – – –
c.*50C>T – LIG3 (rs1052536) and c.1196A>G – XRCC1 (rs25487)
C/C-C/C 23 0.074 32 0.111 1.565 (0.893–2.745) 0.118 1.565 (0.893–2.745) 0.118
C/C-C/T 25 0.080 37 0.128 1.686 (0.988–2.879) 0.056 1.686 (0.988–2.879) 0.056
C/C-T/T 8 0.026 10 0.035 1.362 (0.530–3.501) 0.521 1.361 (0.530–3.498) 0.522
C/T-C/C 65 0.209 46 0.160 0.719 (0.474–1.092) 0.122 0.715 (0.470–1.087) 0.117
C/T-C/T 74 0.238 72 0.250 1.068 (0.735–1.550) 0.731 1.069 (0.736–1.553) 0.726
C/T-T/T 27 0.087 18 0.063 0.701 (0.378–1.303) 0.261 0.702 (0.378–1.303) 0.262
T/T-C/C 42 0.135 30 0.104 0.745 (0.452–1.226) 0.247 0.745 (0.453–1.228) 0.249
T/T-C/T 39 0.125 36 0.125 0.996 (0.614–1.617) 0.988 0.996 (0.614–1.617) 0.987
T/T-T/T 8 0.026 7 0.024 0.944 (0.338–2.636) 0.912 0.947 (0.339–2.651) 0.918
c.*50C>T – LIG3 (rs1052536) and c.2285T>C – PARP1 (rs1136410)
C/C-A/A 39 0.125 57 0.198 1.721 (1.105–2.681) 0.016 1.720 (1.104–2.681) 0.017
C/C-A/G 17 0.055 17 0.059 1.085 (0.543–2.168) 0.818 1.086 (0.543–2.170) 0.815
C/C-G/G 0 - 5 0.017 – – – –
C/T-A/A 108 0.347 89 0.309 0.841 (0.597–1.183) 0.320 0.839 (0.595–1.181) 0.314
C/T-A/G 52 0.167 40 0.139 0.803 (0.514–1.257) 0.338 0.804 (0.514–1.259) 0.341
C/T-G/G 6 0.019 7 0.024 1.266 (0.421–3.813) 0.675 1.263 (0.419–3.807) 0.678
T/T-A/A 54 0.174 45 0.156 0.881 (0.572–1.359) 0.567 0.882 (0.572–1.360) 0.570
T/T-A/G 34 0.109 25 0.087 0.774 (0.450–1.333) 0.356 0.775 (0.450–1.335) 0.359
T/T-G/G 1 0.003 3 0.010 3.263 (0.338–31.550) 0.307 3.250 (0.336–31.466) 0.309
c.*50C>T – LIG3 (rs1052536) and c.-441G>A – FEN1 (rs174538)
C/C-A/A 0 – 0 – – – – –
C/C-A/G 29 0.093 31 0.108 1.173 (0.688–2.000) 0.558 1.172 (0.687–1.999) 0.559
C/C-G/G 27 0.087 48 0.167 2.104 (1.274–3.475) 0.004 2.104 (1.274–3.475) 0.004
C/T-A/A 0 – 0 – – – – –
C/T-A/G 86 0.277 58 0.201 0.660 (0.451–0.965) 0.032 0.658 (0.449–0.963) 0.031
C/T-G/G 80 0.257 78 0.271 1.072 (0.746–1.543) 0.706 1.073 (0.746–1.544) 0.704
T/T-A/A 0 - 0 - – – – –
T/T-A/G 36 0.116 30 0.104 0.888 (0.532–1.484) 0.651 0.890 (0.532–1.489) 0.658
T/T-G/G 53 0.170 43 0.149 0.854 (0.551–1.325) 0.482 0.854 (0.551–1.324) 0.481
c.*83A>C – LIG3 (rs4796030) and c.580C>T – XRCC1 (rs1799782)
A/A-G/G 25 0.080 43 0.149 2.008 (1.192–3.383) 0.009 2.015 (1.195–3.398) 0.009
A/A-G/A 6 0.019 9 0.031 1.640 (0.576–4.666) 0.354 1.637 (0.575–4.660) 0.356
A/A-A/A 0 – 1 0.003 – – – –
A/C-G/G 124 0.399 106 0.368 0.878 (0.631–1.222) 0.441 0.879 (0.632–1.223) 0.444
A/C-G/A 10 0.032 13 0.045 1.423 (0.614–3.297) 0.411 1.423 (0.614–3.297) 0.411
A/C-A/A 1 0.003 1 0.003 1.080 (0.067–17.349) 0.957 1.068 (0.066–14.231) 0.963
C/C-G/G 125 0.402 95 0.330 0.732 (0.524–1.023) 0.068 0.732 (0.524–1.023) 0.068
C/C-G/A 20 0.064 20 0.069 1.086 (0.572–2.063) 0.801 1.082 (0.567–2.061) 0.812
C/C-A/A 0 – 0 – – – – –
c.*83A>C – LIG3 (rs4796030) and c.1196A>G – XRCC1 (rs25487)
A/A-C/C 13 0.042 22 0.076 1.896 (0.937–3.838) 0.075 1.897 (0.937–3.841) 0.075
A/A-C/T 13 0.042 27 0.094 2.371 (1.199–4.691) 0.013 2.374 (1.200–4.698) 0.013
A/A-T/T 5 0.016 4 0.014 0.862 (0.229–3.242) 0.826 0.865 (0.230–3.259) 0.831
A/C-C/C 51 0.164 39 0.135 0.798 (0.508–1.254) 0.329 0.796 (0.507–1.252) 0.324
A/C-C/T 59 0.190 63 0.219 1.196 (0.803–1.781) 0.378 1.199 (0.805–1.787) 0.372
A/C-T/T 25 0.080 18 0.063 0.763 (0.407–1.430) 0.398 0.764 (0.407–1.432) 0.401
C/C-C/C 66 0.212 47 0.163 0.724 (0.478–1.095) 0.126 0.723 (0.478–1.095) 0.126
C/C-C/T 66 0.212 55 0.191 0.876 (0.587–1.308) 0.518 0.875 (0.586–1.306) 0.513
C/C-T/T 13 0.042 13 0.045 1.084 (0.494–2.378 0.841 1.082 (0.493–2.375) 0.844
c.*83A>C – LIG3 (rs4796030) and c.2285T>C – PARP1 (rs1136410)
A/A-A/A 19 0.061 37 0.128 2.265 (1.271–4.039) 0.006 2.268 (1.272–4.044) 0.006
A/A-A/G 12 0.039 14 0.049 1.273 (0.579–2.800) 0.548 1.275 (0.579–2.805) 0.546
A/A-G/G 0 – 2 0.007 – – – –
A/C-A/A 93 0.299 78 0.271 0.871 (0.610–1.242) 0.445 0.870 (0.610–1.242) 0.443
A/C-A/G 37 0.119 37 0.128 1.092 (0.671–1.776) 0.724 1.097 (0.672–1.789) 0.712
A/C-G/G 5 0.016 5 0.017 1.081 (0.310–3.774) 0.902 1.079 (0.309–3.768) 0.905
C/C-A/A 89 0.286 76 0.264 0.894 (0.624–1.281) 0.542 0.893 (0.623–1.279) 0.536
C/C-A/G 54 0.174 31 0.108 0.574 (0.357–0.922) 0.022 0.574 (0.357–0.922) 0.022
C/C-G/G 2 0.006 8 0.028 4.414 (0.930–20.963) 0.062 4.408 (0.928–20.939) 0.062
c.*83A>C – LIG3 (rs4796030) and c.-441G>A – FEN1 (rs174538)
A/A-A/A 0 – 0 – – – – –
A/A-A/G 18 0.058 18 0.063 1.085 (0.553–2.129) 0.812 1.089 (0.554–2.139) 0.805
A/A-G/G 13 0.042 35 0.122 3.171 (1.642–6.125) < 0.001 3.171 (1.642–6.124) <0.001
A/C-A/A 0 – 0 – – – – –
A/C-A/G 71 0.228 49 0.170 0.693 (0.462–1.040) 0.076 0.692 (0.461–1.039) 0.076
A/C-G/G 64 0.206 71 0.247 1.263 (0.860–1.854) 0.234 1.266 (0.862–1.860) 0.229
C/C-A/A 0 – 0 - – – – –
C/C-A/G 62 0.199 52 0.181 0.885 (0.588–1.332) 0.558 0.884 (0.587–1.331) 0.555
C/C-G/G 83 0.267 63 0.219 0.769 (0.528–1.120) 0.171 0.768 (0.527–1.119) 0.169
c.580C>T – XRCC1 (rs1799782) and c.2285T>C – PARP1 (rs1136410)
G/G-A/A 178 0.572 160 0.556 0.934 (0.676–1.290) 0.679 0.934 (0.676–1.291) 0.679
G/G-A/G 90 0.289 72 0.250 0.819 (0.570–1.176) 0.279 0.819 (0.570–1.178) 0.282
G/G-G/G 6 0.019 12 0.042 2.210 (0.818–5.968) 0.118 2.208 (0.818–5.964) 0.118
G/A-A/A 22 0.071 30 0.104 1.527 (0.859–2.715) 0.149 1.528 (0.857–2.727) 0.151
G/A-A/G 13 0.042 10 0.035 0.825 (0.356–1.911) 0.653 0.825 (0.356–1.912) 0.654
G/A-G/G 1 0.003 2 0.007 2.168 (0.196–24.036) 0.528 2.161 (0.195–23.970) 0.530
A/A-A/A 1 0.003 1 0.003 1.080 (0.067–17.349) 0.957 1.068 (0.066–17.231) 0.963
A/A-A/G 0 – 0 – – – – –
A/A-G/G 0 – 1 0.003 – – – –
c.580C>T – XRCC1 (rs1799782) and c.-441G>A – FEN1 (rs174538)
G/G-A/A 0 – 0 – – – – –
G/G-A/G 135 0.434 101 0.351 0.704 (0.506–0.979) 0.037 0.704 (0.506–0.979) 0.037
G/G-G/G 139 0.447 143 0.497 1.220 (0.885–1.683) 0.225 1.224 (0.887–1.689) 0.219
G/A-A/A 0 – 0 – – – – –
G/A-A/G 16 0.051 17 0.059 1.157 (0.573–2.335) 0.685 1.156 (0.573–2.334) 0.685
G/A-G/G 20 0.064 25 0.087 1.383 (0.751–2.548) 0.298 1.382 (0.747–2.556) 0.303
A/A-A/A 0 - 0 - – – – –
A/A-A/G 0 - 1 0.003 – – – –
A/A-G/G 1 0.003 1 0.003 1.080 (0.067–17.349) 0.957 1.080 (0.067–17.354) 0.956
c.1196A>G – XRCC1 (rs25487) and c.2285T>C – PARP1 (rs1136410)
C/C-A/A 84 0.270 77 0.267 0.986 (0.687–1.416) 0.940 0.984 (0.685–1.414) 0.930
C/C-A/G 43 0.138 27 0.094 0.645 (0.387–1.074) 0.092 0.645 (0.387–1.075) 0.093
C/C-G/G 3 0.010 4 0.014 1.446 (0.321–6.517) 0.631 1.449 (0.321–6.532) 0.629
C/T-A/A 88 0.283 90 0.313 1.152 (0.811–1.636) 0.429 1.152 (0.811–1.636) 0.429
C/T-A/G 47 0.151 45 0.156 1.040 (0.667–1.622) 0.862 1.042 (0.668–1.625) 0.858
C/T-G/G 3 0.010 10 0.035 3.693 (1.006–13.556) 0.049 3.691 (1.006–13.549) 0.049
T/T-A/A 29 0.093 24 0.083 0.884 (0.502–1.557) 0.670 0.884 (0.502–1.557) 0.670
T/T-A/G 13 0.042 10 0.035 0.825 (0.356–1.911) 0.653 0.827 (0.356–1.920) 0.659
T/T-G/G 1 0.003 1 0.003 1.080 (0.067–17.349) 0.957 1.068 (0.066–17.231) 0.963
c.1196A>G – XRCC1 (rs25487) and c.-441G>A – FEN1 (rs174538)
C/C-A/A 0 – 0 – – – – –
C/C-A/G 66 0.212 48 0.167 0.742 (0.492–1.121) 0.157 0.739 (0.489–1.118) 0.152
C/C-G/G 64 0.206 60 0.208 1.016 (0.684–1.508) 0.939 1.016 (0.684–1.509) 0.937
C/T-A/A 0 – 0 – – – – –
C/T-A/G 59 0.190 57 0.198 1.054 (0.703–1.581) 0.800 1.055 (0.703–1.583) 0.795
C/T-G/G 79 0.254 88 0.306 1.292 (0.903–1.848) 0.160 1.292 (0.904–1.848) 0.160
T/T-A/A 0 – 0 – – – – –
T/T-A/G 26 0.084 14 0.049 0.560 (0.286–1.095) 0.090 0.561 (0.287–1.097) 0.091
T/T-G/G 17 0.055 21 0.073 1.360 (0.703–2.633) 0.361 1.360 (0.702–2.632) 0.362
c.2285T>C – PARP1 (rs1136410) and c.-441G>A – FEN1 (rs174538)
A/A-A/A 0 – 0 – – – – –
A/A-A/G 100 0.322 78 0.271 0.784 (0.551–1.115) 0.175 0.782 (0.550–1.113) 0.172
A/A-G/G 101 0.325 113 0.392 1.343 (0.960–1.877) 0.085 1.342 (0.960–1.876) 0.085
A/G-A/A 0 – 0 – – – – –
A/G-A/G 47 0.151 36 0.125 0.802 (0.503–1.280) 0.356 0.803 (0.503–1.283) 0.359
A/G-G/G 56 0.180 46 0.160 0.866 (0.564–1.328) 0.508 0.866 (0.565–1.329) 0.511
G/G-A/A 0 – 0 – – – – –
G/G-A/G 4 0.013 5 0.017 1.356 (0.361–5.100) 0.652 1.352 (0.359–5.088) 0.656
G/G-G/G 3 0.010 10 0.035 3.693 (1.006–13.556) 0.049 3.699 (1.007–13.578) 0.049
*

OR adjusted for sex. p<0.05 along with corresponding ORs are in bold; p<0.012 along with corresponding ORs are in bold and italic.