Table 3. Annual seroconversion and seroreversion rate estimates by the superinfection model based on antigen-specific antibodies.
Antigen | Survey | Site | Number of subjects (N = 609) | % seropositive (95%CI) * | Seroconversion rate (95%CI) | Reversion rate (95%CI) |
---|---|---|---|---|---|---|
AMA1 | Rainy season | Dam | 134 | 61.4 (52.7, 69.3) | 0.354 (0.180, 0.696) | 0.299 (0.128, 0.698) |
No Dam | 166 | 64.5 (56.8, 71.4) | 0.369 (0.213, 0.639) | 0.273 (0.137, 0.541) | ||
Both | 300 | 63.1 (57.4, 68.4) | 0.360 (0.236, 0.550) | 0.282 (0.165, 0.480) | ||
Dry season | Dam | 147 | 53.1 (44.9, 61.0) | 0.189 (0.098, 0.365) | 0.179 (0.071, 0.451) | |
No Dam | 162 | 56.5 (48.7, 64.0) | 0.224 (0.127, 0.396) | 0.194 (0.088, 0.427) | ||
Both | 309 | 54.9 (49.3, 60.4) | 0.208 (0.135, 0.321) | 0.189 (0.104, 0.344) | ||
CeITOS | Rainy season | Dam | 134 | 23.5 (17.0, 31.5) | 0.040 (0.019, 0.086) | 0.064 (0.011, 0.374) |
No Dam | 166 | 28.3 (21.9, 35.7) | 0.071 (0.035, 0.144) | 0.135 (0.047, 0.393) | ||
Both | 300 | 26.2 (21.5, 31.5) | 0.055 (0.032, 0.092) | 0.099 (0.040, 0.248) | ||
Dry season | Dam | 147 | 5.4 (2.7, 10.6) | 0.008 (0.001, 0.042) | 0.064 (0.001, 3.281) | |
No Dam | 162 | 6.2 (3.4, 11.2) | 0.007 (0.002, 0.031) | 0.033 (0.000, 7.559) | ||
Both | 309 | 5.8 (3.7, 9.1) | 0.007 (0.002, 0.022) | 0.045 (0.002, 1.217) | ||
CSP | Rainy season | Dam | 134 | 87.1 (80.2, 91.9) | 0.500 (0.292, 0.857) | 0.121 (0.036, 0.410) |
No Dam | 166 | 81.9 (75.3, 87.1) | 0.359 (0.237, 0.545) | 0.077 (0.025, 0.240) | ||
Both | 300 | 84.2 (79.6, 88.0) | 0.414 (0.300, 0.571) | 0.094 (0.042, 0.211) | ||
Dry season | Dam | 147 | 54.4 (46.3, 62.4) | 0.085 (0.052, 0.138) | 0.002 (0.000, 3.270) | |
No Dam | 162 | 49.1 (41.4, 56.8) | 0.072 (0.044, 0.118) | 0.001 (0.000, 2.630) | ||
Both | 309 | 51.6 (46.0, 57.2) | 0.078 (0.055, 0.110) | 0.001 (0.000, 6.680) |
*For each antigen, a seropositivity cut-off was estimated using combined log10-transformed antibody OD data from both communities over the two survey time points (calculated as the back-transformed log10-mean OD of the negative distribution + log10-three times the standard deviation, Fig 2).