Fig. 4.

a Coverage of TCGA hotspot panels (of different sizes) in a validation dataset from the Broad Institute (n = 183). A panel of 400 hotspots delineated in the TCGA dataset is highlighted for ease of interpretation—the 400 most frequent mutations in TCGA cover 55.49% of Broad patients. Even with the 10,000 most frequent mutations in TCGA, only 68% of Broad patients are covered. b The ten most frequent mutations in TCGA are presented with their coverage of TCGA and Broad patients. Three of the top 10 most frequent mutations in TCGA are not seen at all in the Broad dataset