Table 1.
Final fluticasone furoate pharmacokinetic model: log-transformed and untransformed parameter estimates
| Parameter | Ln estimate (95 % CI) | Estimate (95 % CI) | RSE (%) |
|---|---|---|---|
| CL/F (L/h) | 5.44 (5.39, 5.49) | 230 (219, 242) | 0.47 |
| V 2/F (L) | 0.31 FIXED | 1.36 FIXED | FIXED |
| Q/F (L/h) | 5.59 (5.40, 5.78) | 268 (221, 324) | 1.73 |
| V 3/F (L) | 4.71 (4.51, 4.91) | 111 (90.9, 136) | 2.21 |
| (h−1) | −2.95 (−3.01, −2.89) | 0.0523 (0.0493, 0.0556) | 1.06 |
| RACE1 = 2 on CL/F | −0.211 (−0.329, −0.0930) | 0.810 (0.720, 0.911) | 28.5 |
| RACE1 = 3 on CL/F | 0.0602 (−0.175, 0.295) | 1.062 (0.839, 1.343) | 199.0 |
| RACE1 = 4 on CL/F | −0.265 (−0.528, −0.002) | 0.767 (0.590, 0.998) | 50.6 |
CI confidence interval, RSE relative standard error, CL/F inhaled clearance, V 2 /F volume of central compartment, Q/F intercompartmental clearances, V 3 /F volumes of peripheral compartment, absorption rate
RACE1 = 2—East Asian, Japanese, and South Asian; RACE1 = 3—African American; RACE1 = 4 Asian Central, White Arabic, American Indian/Native Alaskan, and other