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. Author manuscript; available in PMC: 2017 Oct 15.
Published in final edited form as: J Immunol. 2016 Oct 15;197(8):2971–2979. doi: 10.4049/jimmunol.1600460

FIGURE 1.

FIGURE 1

Activation of the MAPK family of cell signaling molecules. There are three main families of MAPK: p38, ERK and JNK. Each has important roles in the response of a cell to a stimulus. On the left indicates the normal process of events: A cell stimulus results in the activation of a MAP3K (MAPKKK), which in turn phosphorylates a MAP2K (MAPKK). The MAPKK activates the MAPK via phosphorylation which leads to a biological response. The specific biological responses mediated by the individual MAPKs are indicated on the right.