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. 2016 Nov 21;215(4):499–513. doi: 10.1083/jcb.201608123

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© 2016 Thomas and Fromme

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 7. — Bidirectional feedback between TRAPPII-Ypt31/32 and Sec7-Arf1 orchestrates vesicle trafficking at the TGN. (A) Model for the ordered series of events leading to vesicle formation at the TGN, highlighting the roles of Arf1 in recruiting TRAPPII and Ypt31/32 in stimulating Sec7 activity. (B) Model for the roles of functional physical interactions among TRAPPII, Ypt31/32, Sec7, and Arf1. Interactions of Pik1 homologues with Arf1 and Rab11 have been reported in mammalian and insect cells.