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. 2016 Nov 21;215(4):441–443. doi: 10.1083/jcb.201611014

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© 2016 Farhan

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — Schematic illustration of the mutual regulatory circuits between EGFR signaling and ER export. The top part shows that prolonged EGFR signaling will trigger lysosomal degradation of the receptor, which represents a negative feedback loop. The bottom shows that rapid (via ERK2) and slow (via RNF11) signaling leads to ERES formation at the ER (shown in orange), which conforms to a CFFL. This CFFL eventually leads to improved biosynthetic processing of the EGFR. To emphasize the two different layers of regulation, they have been drawn on differently colored backgrounds: The negative feedback circuit on gray and the CFFL on yellow.