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. 2016 Nov 15;45(5):1135–1147. doi: 10.1016/j.immuni.2016.10.021

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© 2016 The Author(s)

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Expression of Tumor-Infiltrating Treg Cells Protein Signatures in CRC and NSCLC Samples

(A) Representative flow cytometry plots for tumor (purple line) normal (green area) tissue infiltrating Treg cells and peripheral blood Treg cells (blue line) analyzed for the expression of the indicated proteins.

(B) Flow cytometry plots representative of four independent experiments showing suppressive activity of CRC infiltrating Treg cells on proliferation (shown as CFSE dilution) of CD4⁺ effector T cells. First panel shows the inhibitory effect of Treg cells on the effector T cell proliferation in the presence of an isotype control antibody. The other panels show the inhibitory effect of Treg cells that have been preincubated with anti PD-L1 or PD-L2 antibodies. Percentage of proliferating cells are indicated. The calculated division index is 0.26 in the presence of the control antibody; 0.57 in the presence of anti-PDL-1 and 0.39 in the presence of anti-PDL-2. Data are representative of four independent experiments.

See also Figure S4.