Figure 5.
Prognostic Value of Signature Transcripts of Tumor Infiltrating Treg Cells
(A) Kaplan-Meier survival curve comparing the high and low expression of the tumor Treg signature transcripts (CCR8, MAGEH1, LAYN) normalized to the CD3G for the CRC (n = 177) and NSCLC (n = 263) studies. Univariate analysis confirmed a significant difference in overall survival curve comparing patients with high and low expression. Statistical significance was determined by the log-rank test. (CRC: p = 0.05 for CCR8, p = 1.48 × 10−3 for MAGEH1, p = 2.1 × 10−4 for LAYN; NSCLC: p = 0.0125 for CCR8, p = 0.035 for MAGEH1, p = 0.0131 for LAYN.) Each table depicts the Kaplan-Meier estimates at the specified time points.
(B) Expression distributions of CCR8, MAGEH1, and LAYN according to tumor staging at the time of surgery in the cohort of CRC patients.
See also Figure S5.