Table 4.
Cox proportional hazards analysis for risk factors associated with overall survival (n = 176)
| Factors | Univariate analysis | Multivariate analysis |
|---|---|---|
| P value (HR, 95% CI) | P value (HR, 95% CI) | |
| Age | 0.17 | |
| HCV antibody positive | 0.30 | |
| HCV RNA status (SVR) | 0.95 | |
| HBs antigen positive | 0.64 | |
| HBc antibody positive | 0.08 | |
| Platelet counts (×103/μL) | 0.048 (1.13,1.00–1.28) | 0.23 |
| Serum albumin level (g/dL) | 0.045 (2.56,1.02–6.41) | 0.53 |
| Serum total bilirubin level (g/dL) | 0.002 (1.76,1.23–2.51) | 0.013 (1.69,1.12–2.56) |
| Prothrombin time (%) | 0.13 | |
| AFP level (ng/mL) | <.0001 (1.00,1.000–1.001) | 0.002 (1.00,1.000–1.001) |
| AFP‐L3 index >10% | 0.01 (3.33,1.32–8.40) | 0.033 (2.94, 1.09–7.93) |
| DCP level (mAU/mL) | <.0001(1.00, 1.001–1.002) | 0.60 |
| Tumor size (cm) | 0.42 | |
| MFI irregular pattern | 0.001 (7.75, 2.23–27.0) | 0.002 (8.26,2.24–30.3) |
HR, hazard ratio; CI, confidence interval; SVR, sustained viral response; AFP, alpha‐fetoprotein; DCP, des‐gamma‐carboxy prothrombin.