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. 2016 Nov 17;167(5):1229–1240.e15. doi: 10.1016/j.cell.2016.10.046

Figure 3.

Figure 3

Structure of the Mammalian Rescue Complex

(A) Overview of the rescue complex assembled with Pelota (pink) and Hbs1l (brown).

(B) Decoding center of the rescue complex.

(C) Hydrogen-bonding interactions between the β3′-β4′ loop of Pelota (pink) and 18S rRNA nucleotides (yellow).

(D and E) Density corresponding to mRNA in the (D) termination or (E) rescue complexes both assembled on the same (NC-stop) mRNA stalled with the UGA stop codon in the A site. The ribosomal small subunit, P- and E-site tRNAs, and eRF1 or Pelota are indicated.