Figure S3.

Secondary Structure Topology Diagrams of Translational GTPases and Decoding Proteins, Related to Figure 1

(A) Topology diagram of the homologous regions of translational GTPases (e.g., eEF1A, eRF3, and Hbs1l), showing the G domain (red) and the two β-barrel domains (orange and yellow). The motifs important for GTP hydrolysis (Switch 1, Switch 2 (Sw2), and P loop) are highlighted.

(B) Topology diagrams of eRF1 and Pelota, showing the divergent N domains and homologous M and C domains. The locations of the loop harboring the catalytic GGQ motif (blue) and the minidomain (mini) in eRF1 are indicated.