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. 2016 Nov 17;167(5):1229–1240.e15. doi: 10.1016/j.cell.2016.10.046

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© 2016 MRC Laboratory of Molecular Biology

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Figure S4 — Decoding Center Interactions, Related to Figure 1

(A) Decoding center interactions of A/T aa-tRNA (purple) in the elongation complex, demonstrating how Gln61 and cis-Pro62 on a loop of uS12 (orange) can interact, via a water molecule or metal ion, with the mRNA (slate) backbone. Decoding nucleotides of 18S rRNA (yellow) are indicated.

(B–D) EM map density and model showing that the interactions between eRF1 (purple) and stop codon mRNA (slate) remain unchanged in the (B) pre-accommodated (contoured at 8σ), (C) accommodated (contoured at 7σ), and (D) ABCE1-bound complexes (contoured at 8σ).

(E and F) Decoding center interactions of (E) eRF1 (purple) in the termination complex and of (F) Pelota (pink), viewed as in panel (A).