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. 2016 Nov 17;167(5):1229–1240.e15. doi: 10.1016/j.cell.2016.10.046

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© 2016 MRC Laboratory of Molecular Biology

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Figure S7 — Conformational Changes during Decoding Factor Accommodation, Related to Figure 7

(A) The minidomain of pre-accommodated eRF1 (colored by domains) forms an interaction (circled) with eS31 (yellow) that is stabilized by G1507 of 18S rRNA.

(B) Upon accommodation, the M (purple) and C (pale blue) domains of eRF1, and the L7/L12 rRNA stalk base (blue) supporting uL11 (light cyan) undergo conformational changes to establish new interactions (circled) between the eRF1 minidomain with uL11 and the L7/L12 stalk base. Arrows indicate the direction and magnitude of movement of the minidomain and uL11 from the pre-accommodated state.