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. 2016 Nov 23;7:549. doi: 10.3389/fphys.2016.00549

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Copyright © 2016 Yu, Jiang, Jin, Ma and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation effect of quercetin on chloride channel activities in mouse ileum and colon. (A) Activation of CFTR and CaCC-mediated Cl⁻ current in freshly isolated mouse ileum by different concentrations of quercetin. (B) Activation of CFTR and CaCC-mediated Cl⁻ current in colonic epithelia by different concentrations of quercetin. The corresponding histogram of each trace compares the I_sc obtained from different concentrations of quercetin. (C) Inhibition of CFTR-mediated Cl⁻ current by indicated CaCC_inh-A01 in mouse ileum. (D) Inhibition of CFTR chloride channel activity by CFTR_inh-172 (100 μM).