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. 2016 Nov 23;8:282. doi: 10.3389/fnagi.2016.00282

Figure 1.

Figure 1

Transplantation of human brain-derived neural stem cells (hNSCs) into hippocampal CA1 region of amyloid precursor protein (APP)/presenilin 1 (PS1; Alzheimer’s disease, AD) mice. (A) Schematic drawing of a typical coronal brain section, illustrating the distribution of engrafted green fluorescent protein (GFP)-labeled cells (green dots). Asterisks represent the transplantation sites. Lowercase letters indicate sites where corresponding images (B–G) were taken. (B,C) Transplanted hNSCs engrafted into the hippocampus, and they migrated extensively into corpus callosum (D), frontal cortex (E), thalamus (F) and external capsule (G). (H,I) GFP-labeled hNSCs co-localized well with 4′,6-diamidino-2-phenylindole (DAPI; white arrow). Some of hNSCs differentiated into GFAP-astrocytes or mature neurons (J–R). There was no significant difference in counts between GFP-labeled and GFP/DAPI co-labeled cells (ns. = p > 0.05). Scale bar: 50 μm.