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. 2016 Nov 23;8:282. doi: 10.3389/fnagi.2016.00282

Figure 2.

Figure 2

hNSCs rescued recognition, learning and memory function but not anxiety level in APP/PS1 mice. (A) Analysis of open field test (OFT) tests. There was no significant difference in frequencies of mobile, immobile and highly mobile states, as well as % of duration in periphery and central zones between the PBS and NSC group (ns. = p > 0.05), #p < 0.05 vs. wild-type (WT) mice. (B) There was no difference in discrimination index (DI) between the WT and NSC group (ns. = p > 0.05), **p < 0.01 vs. the PBS group. (C) Escape latencies in five training days of the morris water maze (MWM). Significant interactions were found for the latency from training day 2 (*p < 0.05; **p < 0.01), where NSC group mice decreased the latency to the hidden platform. No significant difference in latencies was found between the NSC and WT group (ns. = p > 0.05). (D) Representative training (5th day) and probe traces of mice in three groups. (E) Analysis of the probe test. There was no significant difference in % of distance traveled in target quadrant, mean speed and number of crossings between the WT and NSC group (ns. = p > 0.05), *p < 0.05; **p < 0.01 vs. the PBS group.